Team:Valencia Biocampus/Modeling
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Here we modeled several of the Bacteria constructions. | Here we modeled several of the Bacteria constructions. | ||
Revision as of 11:22, 26 September 2012
Modeling
Mathematical modeling: Introduction
Mathematical modeling plays a central role in Synthetic Biology, one of its mayor abilities: to predict the behavior of a biological circuit and then is an important bridge between the ideas and concepts, and biological experiments.
The main idea is to interact with the experimental part of the project in two ways. In one hand to characterize the constructed biobricks and identify parameters of the models allowing to a better understanding of the biology behind and on the other hand to direct the way in which experiments are performed to verify a prediction from the modeling.
Then we started the characterization of each part created in the lab, some of the mathematical model parameters were estimated thanks to several experiments we performed within the project (others were derived from literature) and they were used to predict the final behavior of each construction.
Experimental procedures for parameter estimation are discussed and simulation experiments performed, using ODEs with MATLAB and Global optimization algorithm for MINLP's based on Scatter Search (SSm by Process Engineering Group IIM-CSIC).