Team:Grenoble/Biology/Notebook/June

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iGEM Grenoble 2012

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Week 23: June 04th to 10th

During this week we chose the project on which we wanted to work.

We decided to create a system which can detect a pathogene, like Staphylococcus aureus, for example.

We intend to build an ultra sensitive detector. The goal is to produce a detector which can hugely amplify a really low input signal. It consists of three modules:
  1. the first gets the signal
  2. the second amplifies it
  3. the third sends the output
The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency. The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated.

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