Team:Grenoble/Modeling/Notebook/August/33

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iGEM Grenoble 2012

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Project

August

Week 31 • Week 32 • Week 33 • Week 34 • Week 35

Week 33: August 13th to 19th


Goal
  • End of the script for the stochastic and analysis
  • Beginning of the equilibrium analysis to answer the question : Is the system always turned on ?
  • Set a new deterministic model for the receptor

Completion
    The script is definitely done but the parameters are not fixed. Thus we can't make simulations and analyse the results.
    We learnt how to use isoclines.
    For the receptor we chose a phenomenological extension of Goldbeter-Koshland biochemical switch model[1].
    The system is now much simple. We have 2 equations and 8 parameters.


      [1] Alejandra C.Ventura, Jacques-A. Sepulchre, Sofia D.Merajver. A Hidden Feedback in Signaling Cascades Is Revealed. PLOS Computational Biology, 2008, 4, 3, e1000041.

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