LAB ESCAPE: Can you escape the lab?

Creating LAB ESCAPE: A Synthetic Biology Video Game

The iGEM 2012 Calgary team ventured into new territory by developing a video game centered on synthetic biology called LAB ESCAPE. As scientists, we are often asked, “What exactly do you do all day?” and “What do you mean you can see DNA?” Our video game provides an opportunity to educate and entertain the player by guiding them through a routine experiment used by the iGEM 2012 Calgary team. LAB ESCAPE focuses on gel electrophoresis – a common molecular biology technique to separate and visualize DNA from PCR and restriction digests. We also incorporated basic laboratory safety procedures to further immerse the player in the research experience.

LAB ESCAPE is part science, part fun, and all iGEM.

From Storyboard to Application

The initial stage in the development of LAB ESCAPE focused on creating an engaging environment resembling a typical synthetic biology research lab. We then worked to create a script outlining the players actions as they begin by finding themselves locked in the lab, progress through the tasks to find the secret code and (hopefully) escape the lab. We originally wanted to incorporate numerous experiments, but focused the game on one common technique (''i.e.'': gel electrophoresis) to avoid over-whelming the player with multiple techniques and keeping the time requirement to a more optimal level. Once the general story was established, we took the next steps to create the digital version.

LAB ESCAPE was created using Adobe Flash and Illustrator. Members of the 2012 iGEM Calgary team created every graphical image and programming code using Adobe Illustrator and Adobe Flash, respectively. Note some programming code was modified from open-source code online. From here we designed a ‘point-and-click’ adventure video game platform, where the user collects items required to complete a task. For LAB ESCAPE, these items were materials needed for a gel electrophoresis experiment, which provided a ‘code’ to allow the user to escape the locked lab.

After compiling the first build (i.e.: Pre-Alpha), we tested the game amongst our team, received comments, and optimized the game further. These comments helped improved the user interface and increase the content within the video game. Following a couple more versions, we started to share LAB ESCAPE among our friends, family and anyone willing to try our video game for more all-important feedback. By September 2012, we had a completely functional video game and asked if we could premiere the video game to the public at the [http://www.sparkscience.ca TELUS SPARK] science centre here in Calgary. !!!!!!! On September 29-30th we hosted an 2012 iGEM Calgary event for LAB ESCAPE, where several hundred people got to play and learn about synthetic biology – incredible fun!! !!!!!!!! We expect that several more people – scientists and non-scientists alike – will play, learn, and enjoy LAB ESCAPE as our iGEM wiki goes live in early October.

Can you escape LAB ESCAPE?

In general, LAB ESCAPE is a ‘point-and-click’ adventure. The user begins the game locked in the classroom (which is attached to the research lab) and must find a numerical code to exit. Using your cursor, you must collect DNA tubes to run the gel electrophoresis experiment (in the research lab). Once ran, the banding pattern of the DNA on the gel must match the assembled gel photo (from collected pieces throughout the two rooms) to provide a number code that unlocks the door to exit the lab.

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