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Team:Grenoble/Project/Abstract
From 2012.igem.org
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<h1>Project Description</h1> | <h1>Project Description</h1> | ||
<p> | <p> | ||
| - | The Grenoble iGEM team intends to build an ultra sensitive detector. The goal is to produce a detector | + | The Grenoble iGEM team intends to build an ultra sensitive detector. The goal is to produce a detector which can greatly amplify an extremely low input signal. It consists of three modules:<br/> |
| - | <br/> | + | |
<ol> | <ol> | ||
<li>the first gets the signal</li> | <li>the first gets the signal</li> | ||
| Line 15: | Line 14: | ||
</ol> | </ol> | ||
<br/> | <br/> | ||
| - | The detection module is a membrane receptor that once activated by a | + | The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency. <br/> |
| - | The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. | + | The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated. <br/> |
| - | Once amplified and filtered the signal is transmitted to the neighboring bacteria. | + | |
| - | In this way a noticeable fluorescent emission is generated. <br/> | + | |
<br/> | <br/> | ||
| - | <h4>Scheme of the concept</h4> | + | <center> <h4>Scheme of the concept</h4> </center> |
| - | <img src="https://static.igem.org/mediawiki/2012/9/9d/Schema1.png" alt="Scheme of the concept" style="horizontal-align: center;"/> | + | <center><img src="https://static.igem.org/mediawiki/2012/9/9d/Schema1.png" alt="Scheme of the concept" style="horizontal-align: center;"/></center> |
| - | + | ||
| - | + | ||
| - | + | ||
| - | </ | + | <center> <h4>Theoretical response of the device depending on the input signal</h4> <br/> |
| + | <img src="https://static.igem.org/mediawiki/2012/c/cf/Schema2.png" alt="Theoretical response of the device depending on the input signal" style="horizontal-align: center;"/></center> | ||
</section> | </section> | ||
Revision as of 16:53, 11 August 2012
Project Description
The Grenoble iGEM team intends to build an ultra sensitive detector. The goal is to produce a detector which can greatly amplify an extremely low input signal. It consists of three modules:
- the first gets the signal
- the second amplifies it
- the third sends the output
The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency.
The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated.
Scheme of the concept
Theoretical response of the device depending on the input signal
