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Team:Grenoble/Modeling/Notebook/August/33
From 2012.igem.org
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We learnt how to use isoclines. | We learnt how to use isoclines. | ||
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| - | For the receptor we chose a phenomenological extension of Goldbeter-Koshland biochemical switch model[1]. </br>The system is now much simple. We have 2 equations and 8 parameters. | + | For the receptor we chose a phenomenological extension of Goldbeter-Koshland biochemical switch model[1]. </br>The system is now much simple. We have 2 equations and 8 parameters.</br></br> |
| - | </ | + | |
[1] Alejandra C.Ventura, Jacques-A. Sepulchre, Sofia D.Merajver. A Hidden Feedback in Signaling Cascades Is Revealed. PLOS Computational Biology, 2008, 4, 3, e1000041. | [1] Alejandra C.Ventura, Jacques-A. Sepulchre, Sofia D.Merajver. A Hidden Feedback in Signaling Cascades Is Revealed. PLOS Computational Biology, 2008, 4, 3, e1000041. | ||
| + | </ul> | ||
</section> | </section> | ||
</div> | </div> | ||
Revision as of 17:04, 22 September 2012
August
Week 31 • Week 32 • Week 33 • Week 34 • Week 35Week 33: August 13th to 19th
Goal- End of the script for the stochastic and analysis
- Beginning of the equilibrium analysis to answer the question : Is the system always turned on ?
- Set a new deterministic model for the receptor
-
The script is definitely done but the parameters are not fixed. Thus we can't make simulations and analyse the results.
We learnt how to use isoclines.
For the receptor we chose a phenomenological extension of Goldbeter-Koshland biochemical switch model[1]. The system is now much simple. We have 2 equations and 8 parameters.
[1] Alejandra C.Ventura, Jacques-A. Sepulchre, Sofia D.Merajver. A Hidden Feedback in Signaling Cascades Is Revealed. PLOS Computational Biology, 2008, 4, 3, e1000041.
