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Team:Grenoble/Biology/Network
From 2012.igem.org
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The dipeptide bind to his receptor which is an engineered receptor: | The dipeptide bind to his receptor which is an engineered receptor: | ||
| - | <ul><li>the extracellular part is the extracellular part of Tap, a dipeptide receptor involved in the chemotaxism<li> | + | <ul><li>the extracellular part is the extracellular part of Tap, a dipeptide receptor involved in the chemotaxism</li> |
| - | <li>the intracellular part is the intracellular part of EnvZ, an osmolarity sensor protein<li> | + | <li>the intracellular part is the intracellular part of EnvZ, an osmolarity sensor protein</li> |
| - | </ul> | + | </ul> |
| + | Once the dipeptide is bound, the EnvZ part allows the phosphorylation of OmpR | ||
</section> | </section> | ||
Revision as of 21:26, 23 September 2012
Network details
Signaling module
The signaling module allows our bacterial strain to integrate the input signal = the pathogene presence.Stapylococcus aureus secrete a protease nom de la protéase which cut a specific amino-acids sequence. This specific sequence can be used as a linker between a membrane protein and a dipeptide.
Once S. aureus is present, the linker is cut by the protease and the dipeptide is released.
The dipeptide bind to his receptor which is an engineered receptor:
- the extracellular part is the extracellular part of Tap, a dipeptide receptor involved in the chemotaxism
- the intracellular part is the intracellular part of EnvZ, an osmolarity sensor protein
