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Team:Grenoble/Biology/Notebook/June
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<a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_26">Week 26</a> | <a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_26">Week 26</a> | ||
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<h1> Week 23: June 04<span class="exposant">th</span> to 10<span class="exposant">th</span> </h1> | <h1> Week 23: June 04<span class="exposant">th</span> to 10<span class="exposant">th</span> </h1> | ||
Revision as of 13:14, 20 August 2012
June
Week 23 • Week 24 • Week 25 • Week 26Week 23: June 04th to 10th
During this week we chose the project on which we wanted to work.We decided to create a system which can detect a pathogene, like Staphylococcus aureus, for example.
We intend to build an ultra sensitive detector. The goal is to produce a detector which can greatly amplify an extremely low input signal. It consists of three modules:
- the first gets the signal
- the second amplifies it
- the third sends the output
The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency.
The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated.
Scheme of the concept
Theoretical response of the device depending on the input signal
