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Team:Grenoble/Biology/Notebook/June/week 25
From 2012.igem.org
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<a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_25">Week 25</a> • | <a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_25">Week 25</a> • | ||
<a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_26">Week 26</a> | <a href="https://2012.igem.org/Team:Grenoble/Biology/Notebook/June/week_26">Week 26</a> | ||
| - | </section><br/> | + | </section> |
| + | <br/> | ||
<br/> | <br/> | ||
<section> | <section> | ||
| - | <h1> Week | + | <h1> Week 23: June 04<span class="exposant">th</span> to 10<span class="exposant">th</span> </h1> |
| - | + | During this week we chose the project on which we wanted to work. <br/> | |
| - | + | ||
<br/> | <br/> | ||
| - | < | + | We decided to create a system which can detect a pathogene, like <i>Staphylococcus aureus</i>, for example.<br/> |
<br/> | <br/> | ||
| - | We | + | We intend to build an ultra sensitive detector. The goal is to produce a detector which can greatly amplify an extremely low input signal. It consists of three modules:<br/> |
| + | <ol> | ||
| + | <li>the first gets the signal</li> | ||
| + | <li>the second amplifies it</li> | ||
| + | <li>the third sends the output</li> | ||
| + | </ol> | ||
<br/> | <br/> | ||
| - | + | The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency. <br/> | |
| - | + | The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated. <br/> | |
| - | + | ||
<br/> | <br/> | ||
| + | <center> <h4>Scheme of the concept</h4> </center> | ||
| + | <center><img src="https://static.igem.org/mediawiki/2012/9/9d/Schema1.png" alt="Scheme of the concept" style="horizontal-align: center;"/></center> | ||
| + | |||
| + | <center> <h4>Theoretical response of the device depending on the input signal</h4> <br/> | ||
| + | <img src="https://static.igem.org/mediawiki/2012/c/cf/Schema2.png" alt="Theoretical response of the device depending on the input signal" style="horizontal-align: center;"/></center> | ||
| + | |||
</section> | </section> | ||
| + | <br/> | ||
| + | <br/> | ||
</div> | </div> | ||
</body> | </body> | ||
Revision as of 12:26, 20 August 2012
June
Week 23 • Week 24 • Week 25 • Week 26Week 23: June 04th to 10th
During this week we chose the project on which we wanted to work.We decided to create a system which can detect a pathogene, like Staphylococcus aureus, for example.
We intend to build an ultra sensitive detector. The goal is to produce a detector which can greatly amplify an extremely low input signal. It consists of three modules:
- the first gets the signal
- the second amplifies it
- the third sends the output
The detection module is a membrane receptor that once activated by a biomolecule actuates an amplification loop. The loop enhances the cell response efficiency.
The amplification system contains a genetic feed forward loop. It acts as a biologic loud filter aiming at reducing false positive outputs. Once amplified and filtered the signal is transmitted to the neighboring bacteria. In this way a noticeable fluorescent emission is generated.
Scheme of the concept
Theoretical response of the device depending on the input signal
