Team:UNAM Genomics Mexico

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<center><h1>'''Welcome to our homepage'''</h1></center>
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<h1>Welcome to our homepage still under construction.</h1>  
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<h2>'''Bacillus booleanus'''</h2>  
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A logic gate is an idealized (or physical) device implementing a Boolean function that performs a logic operation on one or more logic inputs and produces a single logic output. A single logic gate is not a computer, many of them are necessary and they need to communicate with each other to compute stuff. In this way, a complex logic system can be created, like a computer. The architecture of gene regulatory networks is reminiscent of electronic circuits. Modular building blocks that respond in a logical way to one or several inputs are connected to perform a variety of complex tasks. Taking these two main ideas, it could be possible to create a “biological computer”. Bacillus booleanus is a project that wants to link several Boolean operations to make the beginnings of a biological computer. How does everything work? We are working on the creation of different strains of Bacillus subtilis. Each one will be able to perform a single Boolean operation, just like transistors do in an electronic computer. As we mentioned, our bacteria need to communicate to achieve trascendence, but how could this be possible? In 2011 Ben-Yehuda et. al. identified a type of bacterial communication mediated by nanotubes that bridge neighboring cells, providing a network for exchange of cellular molecules within, and between species. By using these nanotubes, our bacteria will be capable to communicate with others, creating complex networks of logic gates. Using this, it could be possible to develop a complex network of operators to regulate, for example, a synthetic metabolic pathway.
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<td id="leftcolumn2"align="center"><img src="https://static.igem.org/mediawiki/2012/d/d2/Unamgenomicsnanotubes.jpg" alt="some_text" height="190"/><br /><br /><p>Nanotubes</p></td>
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<h1>We found Nanotubes!!!</h1>
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<td  id="contentcolumn2" align="center"><img src="https://static.igem.org/mediawiki/2012/c/cd/UnamgenomicsLogiv.jpg" alt="some_text" height="200"/><br /><br /><p>The Logic</p></td>
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[[File:UnamgenomicsNanocirculorojo.jpg|510px|link=Team:UNAM_Genomics_Mexico/Results/Nanotubes]]
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<b>More info here</b>
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<td id="rightcolumn2" align="center"><a href="https://static.igem.org/mediawiki/2012/6/6d/UnamgenomicsCRATELBIOSINTEtizartegrande.jpg"><img src="https://static.igem.org/mediawiki/2012/f/f1/CRATELBIOSINTEtizartechico.jpg" alt="some_text" height="170"/><br /><br /><p>Convocatoria</p></a</td>
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<h1>Regional Jamboree!!!</h1>
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[[File:Unamgenomicsbestwikihome.JPG|300px|link=Team:UNAM_Genomics_Mexico/Notebook/Photos]]<br />
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[[File:Unamgenomicsbogotahome.JPG|300px|link=Team:UNAM_Genomics_Mexico/Notebook/Photos]]<br />
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<b>Regional Jamboree LOTS of FUN!</b>
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<h1>Project description</h1>
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<td id="leftcolumn2"align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/HumanPractices/Who_is_Mrs._Cohnnie_PhD?"><img src="https://static.igem.org/mediawiki/2012/6/60/UnamgenomicsmissLogomujer.png" alt="some_text" height="190"/><br /><br /><p><b>Meet Mrs. Lupita Cohnnie, PhD</b></p></a></td>
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<h2>BACILLUS BOOLEANUS</h2>
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A logic gate is an idealized or physical device implementing a Boolean function, that performs a logical operation on one or more logic inputs and produces a single logic output. To build a functionally complete logic system, transistors can be used. A single transistor is not a computer, many of them are necessary and they need to communicate with each other, in this way a complex logic system can be created. The architecture of gene regulatory networks is reminiscent of electronic circuits. Modular building blocks that respond in a logical way to one or several inputs are connected to perform a variety of complex tasks. Taking these two main ideas, it could be possible to create a “molecular computer”. Bacillus Booleanus is a project that wants to create a “molecular computer”. How does it work? We are working on the creation of different strains of ''Bacillus subtilis''. Each one of them will be able to perform a single Boolean operation just like a transistor. As we mentioned, our transistors need to communicate, but how could this be possible? In [https://static.igem.org/mediawiki/2012/0/0f/Nanotubes.pdf 2011 Ben-Yehuda et. al]. identified a type of bacterial communication mediated by nanotubes that bridge neighboring cells, providing a network for exchange of cellular molecules within and between species. By using these nanotubes our bacterium will be capable to communicate with others, creating complex networks of logic gates. Using this, it could be possible to develop a complex network of "transistors" to create, for example, a synthetic metabolic pathway.
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1 Gyanendra P. Dubey, Sigal Ben-Yehuda. Intercellular Nanotubes Mediate Bacterial Communication. Cell, 2011; 144 (4): 590 DOI:10.1016/j.cell.2011.01.015
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<td  id="contentcolumn2" align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/Notebook/Videos"><img src="https://static.igem.org/mediawiki/2012/b/b7/UnamgenomicsVideos.png" alt="some_text" height="200"/><br /><br /><p><b>Our Videos</b></p></a></td>
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2 Schlief, R. Regulation of the L-arabinose operon of Escherichia coli. Trends in Genetics, 2000; 16(12):559-565.
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<td id="rightcolumn2" align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/Modeling"><img src="https://static.igem.org/mediawiki/2012/e/e2/UnamgenomicsModelwelcome.png" alt="some_text" height="170"/><br /><br /><p><b>Our Model</b></p></a></td>
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<td id="leftcolumn3"align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/Results/Nanotubes"><img src="https://static.igem.org/mediawiki/2012/d/d2/Unamgenomicsnanotubes.jpg" alt="some_text" height="190"/><br /><br /><p><b>Nanotubes</b></p></a></td>
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3 Kreuzer P, Gärtner D, Allmansberger R, Hillen W. Identification and sequence analysis of the Bacillus subtilis W23 xylR gene and xyl operator. J Bacteriol. 1989 Jul;171(7):3840-5.
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<td  id="contentcolumn3" align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/Project/DeeperDescription"><img src="https://static.igem.org/mediawiki/2012/c/cd/UnamgenomicsLogiv.jpg" alt="some_text" height="200"/><br /><br /><p><b>The System Logic</b></p></a></td>
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4 Newcastle University iGEM team. 2009. <<https://2009.igem.org/Team:Newcastle/Project#Cadmium_Sensing>>
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<td id="rightcolumn3" align="center"><a href="https://2012.igem.org/Team:UNAM_Genomics_Mexico/HumanPractices/BiosintetizarteEN"><img src="https://static.igem.org/mediawiki/2012/f/f1/CRATELBIOSINTEtizartechico.jpg" alt="some_text" height="170"/><br /><br /><p><b>Call</b></p></a></td>
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5 Moore CM, Helmann JD. Metal ion homeostasis in Bacillus subtilis. Curr Opin Microbiol. 2005 Apr;8(2):188-95.
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Latest revision as of 02:51, 27 October 2012


UNAM-Genomics_Mexico

Welcome to our homepage


Bacillus booleanus


A logic gate is an idealized (or physical) device implementing a Boolean function that performs a logic operation on one or more logic inputs and produces a single logic output. A single logic gate is not a computer, many of them are necessary and they need to communicate with each other to compute stuff. In this way, a complex logic system can be created, like a computer. The architecture of gene regulatory networks is reminiscent of electronic circuits. Modular building blocks that respond in a logical way to one or several inputs are connected to perform a variety of complex tasks. Taking these two main ideas, it could be possible to create a “biological computer”. Bacillus booleanus is a project that wants to link several Boolean operations to make the beginnings of a biological computer. How does everything work? We are working on the creation of different strains of Bacillus subtilis. Each one will be able to perform a single Boolean operation, just like transistors do in an electronic computer. As we mentioned, our bacteria need to communicate to achieve trascendence, but how could this be possible? In 2011 Ben-Yehuda et. al. identified a type of bacterial communication mediated by nanotubes that bridge neighboring cells, providing a network for exchange of cellular molecules within, and between species. By using these nanotubes, our bacteria will be capable to communicate with others, creating complex networks of logic gates. Using this, it could be possible to develop a complex network of operators to regulate, for example, a synthetic metabolic pathway.

We found Nanotubes!!!

UnamgenomicsNanocirculorojo.jpg More info here

Regional Jamboree!!!

Unamgenomicsbestwikihome.JPG

Unamgenomicsbogotahome.JPG
Regional Jamboree LOTS of FUN!

some_text

Meet Mrs. Lupita Cohnnie, PhD

 some_text

Our Videos

 some_text

Our Model
some_text

Nanotubes

 some_text

The System Logic

 some_text

Call

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