Team:Paris Bettencourt/Overview

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iGEM Paris Bettencourt 2012


Project Overview

Contents

Objectives

Our project aims to:

  • Raise the issue of biosafety, and advocate the discerning use of biosafety circuits in future iGEM projects as a requirement
  • Evaluate the risk of HGT in different SynBio applications
  • Develop a new, improved containment system to expand the range of environments where GEOs can be used safely.

To do so, we:

  • Engaged the general public and scientific community through debate
  • Raised the question about how we can regulate this practices
  • Compiled a parts page of safety circuits in the registry
  • Relied on three levels of containment :
    1. Physical containment with alginate capsules
    2. Semantic containment using an amber suppressor system
    3. An improved killswitch featuring delayed population-level suicide through complete genome degradation.

We strived to make our system as robust against mutations as possible.

General recommandation for a good killswitch device

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Step 1

Step 2

Step 2.

Step 3

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