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Team:TU-Delft/Notebook
From 2012.igem.org
Week 23
On Tuesday we ordered the constructs that we designed to let them synthesize. An exciting moment! Last check: are all the illegal restriction sites removed, is the gene in frame, is it codon-optimized, do we have the prefix and the suffix... yes? GO!
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Week 23
The diffusion model is complete and will be adapted according to the experiment design. The biochemical model structure has been designed, the modellers will be busy trying to fit the model to data this week and replicate the pheromone response The Bioinformatics model for checking the ligand binding is in it's design phase, we are hoping to get it ready in three weeks time
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The reduced model of the pathway is complete and the responses are similar to those obtained from the paper. The next week will be spent doing some analysis of the model and then look to incorporate stochasticity into the model
Week 32
Last week the structural modeling got a nice boost! A member of the SARA institute helped us out in setting up Virtual Machines to execute our Molecular Dynamics Simulations. With the results of these simulations, certain point-mutations in the DNA sequence of the receptor and specific chemicals, we will be able to determine how the ligand will be docked in the niacin receptor. From there, we might be able to engineer a receptor with higher affinity for our ligand.
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Week 22
2-6-2012 Eftychia, Yifan and Mark representing our group partipate at De Nacht van Kunst & Wetenschap!!! It was great experience. We had 3 games: "smelling game" where people had to guess each odor and write down their predictions, the "lego receptor" showing how the receptor can match only with a specific molecule and one more game showing the fluorescence produced when a compound comes in contact with yeast. It was so exciting that more and more people were willing to know more about our project!
Week 23
This Monday Esengul, Marcel and Sietske traveled to the south of the country to go to the opening of the Biobased Kidshouse at the Floriade. We did a workshop with the children where they could make a necklace with their own DNA in it. It was a very, very rainy day but the faces of the children when they saw their own DNA precipitate, was all worth it!
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Check out the logo that Lizah prepared this week for our team that will participate in LowLabs!!
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