Team:TU-Delft/part3

Introduction

Niacin olfactory receptor

The receptors GPR109A and GPR109B are known to bind the compound nicotinic acid [1]. It was previously described that GPR109B acts a low affinity receptor for nicotinic acid and GPR109A acts as a high affinity receptor for nicotinic acid and other compounds with related pharmacology [molecular identification of high and low affinity receptors]. The chemical compound methyl nicotinate is closely related to nicotinic acid. Because one of the compounds in the breath of tuberculosis patients is methyl nicotinate [2,3], the high affinity receptor for niacin is a good candidate for testing the ‘olfactory yeast’ as a diagnostics tool.

Isoamylacetate olfactory receptor

Human receptor OR1G1 and mouse receptor Olfr154 are known to bind the molecule Iso-amyl acetate, an odorant molecule having the banana smell.

Parts

Results

References

[1] Alan Wise, Steven M. Foord, Neil J. Fraser, Ashley A. Barnes,e Nabil Elshourbagy, Michelle Eilert,g Diane M. Ignarg Paul R. Murdock, Klaudia Steplewski,h Andrew Green,Andrew J. Brown, Simon J. Dowell, Philip G. Szekeres, David G. Hassall, Fiona H. Marshall,a, j Shelagh Wilson, and Nicholas B. Pike Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid, The journal of biological chemistry (2003)
[2] Georgies F. Mgode Bart J. Weetjens Thorben Nawrath, Christophe Cox, Maureen Jubitana, Robert S. Machang’, Stéphan Cohen-Bacrie,e Marielle Bedotto, Michel Drancourt,e Stefan Schulz and Stefan H. E. Kaufmann, Diagnosis of Tuberculosis by Trained African Giant Pouched Rats and Confounding Impact of Pathogens and Microflora of the Respiratory Tract, Journal of clinical microbiology (2011)
[3] Mona Syhre, Stephen T. Chambers, The scent of Mycobacterium tuberculosis, Elsevier (2008)

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