Team:NTU-Taida

From 2012.igem.org

(Difference between revisions)
(Replaced content with "{{:Team:NTU-Taida/Templates/Header}}{{:Team:NTU-Taida/Templates/Navbar}}<html> <!--跨頁========================================= --> <div style=' width: 100%; '> <div cla...")
 
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<html>
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{{:Team:NTU-Taida/Templates/Header}}{{:Team:NTU-Taida/Templates/Navbar}}<html>
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<head>
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<!--跨頁========================================= -->
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<style type="text/css">
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<div style='
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width: 100%;
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'>
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  <div class="container">
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    <div class='row'>
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      <img src='https://static.igem.org/mediawiki/2012/5/53/NTU-Taida-Home-2012.jpg' width='100%'>
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    </div>
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  </div> <!-- /container -->
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</div>
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.nav {
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</html>{{:Team:NTU-Taida/Templates/Footer|ActiveNavbar=Home}}
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  margin-bottom: 18px;
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  margin-left: 0;
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  list-style: none;
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}
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.nav > li > a {
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  display: block;
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}
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.nav > li > a:hover {
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  text-decoration: none;
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  background-color: #eeeeee;
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}
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.nav > .pull-right {
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  float: right;
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}
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.nav .nav-header {
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  display: block;
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  padding: 3px 15px;
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  font-size: 11px;
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  font-weight: bold;
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  line-height: 18px;
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  color: #999999;
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  text-shadow: 0 1px 0 rgba(255, 255, 255, 0.5);
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  text-transform: uppercase;
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}
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.nav li + .nav-header {
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  margin-top: 9px;
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}
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.nav-tabs,
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.nav-pills {
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  *zoom: 1;
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}
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.nav-tabs:before,
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.nav-pills:before,
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.nav-tabs:after,
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.nav-pills:after {
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  display: table;
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  content: "";
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}
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.nav-tabs:after,
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.nav-pills:after {
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  clear: both;
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}
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.nav-tabs > li,
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.nav-pills > li {
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  float: left;
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}
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.nav-tabs > li > a,
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.nav-pills > li > a {
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  padding-right: 12px;
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  padding-left: 12px;
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  margin-right: 2px;
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  line-height: 14px;
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}
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.nav-tabs {
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  border-bottom: 1px solid #ddd;
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}
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.nav-tabs > li {
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  margin-bottom: -1px;
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}
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.nav-tabs > li > a {
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  padding-top: 8px;
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  padding-bottom: 8px;
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  line-height: 18px;
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  border: 1px solid transparent;
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  -webkit-border-radius: 4px 4px 0 0;
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    -moz-border-radius: 4px 4px 0 0;
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          border-radius: 4px 4px 0 0;
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}
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.nav-tabs > li > a:hover {
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  border-color: #eeeeee #eeeeee #dddddd;
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}
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.nav-tabs > .active > a,
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.nav-tabs > .active > a:hover {
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  color: #555555;
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  cursor: default;
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  background-color: #ffffff;
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  border: 1px solid #ddd;
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  border-bottom-color: transparent;
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}
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.nav-pills > li > a {
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  padding-top: 8px;
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  padding-bottom: 8px;
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  margin-top: 2px;
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  margin-bottom: 2px;
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  -webkit-border-radius: 5px;
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    -moz-border-radius: 5px;
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          border-radius: 5px;
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}
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.nav-pills > .active > a,
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.nav-pills > .active > a:hover {
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  color: #ffffff;
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  background-color: #0088cc;
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}
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.nav-stacked > li {
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  float: none;
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}
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.nav-stacked > li > a {
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  margin-right: 0;
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}
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.nav-tabs.nav-stacked {
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  border-bottom: 0;
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}
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.nav-tabs.nav-stacked > li > a {
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  border: 1px solid #ddd;
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  -webkit-border-radius: 0;
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    -moz-border-radius: 0;
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          border-radius: 0;
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}
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.nav-tabs.nav-stacked > li:first-child > a {
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  -webkit-border-radius: 4px 4px 0 0;
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    -moz-border-radius: 4px 4px 0 0;
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          border-radius: 4px 4px 0 0;
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}
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.nav-tabs.nav-stacked > li:last-child > a {
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  -webkit-border-radius: 0 0 4px 4px;
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    -moz-border-radius: 0 0 4px 4px;
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          border-radius: 0 0 4px 4px;
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}
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.nav-tabs.nav-stacked > li > a:hover {
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  z-index: 2;
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  border-color: #ddd;
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}
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.nav-pills.nav-stacked > li > a {
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  margin-bottom: 3px;
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}
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.nav-pills.nav-stacked > li:last-child > a {
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  margin-bottom: 1px;
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}
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.nav-tabs .dropdown-menu {
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  -webkit-border-radius: 0 0 5px 5px;
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    -moz-border-radius: 0 0 5px 5px;
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          border-radius: 0 0 5px 5px;
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}
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.nav-pills .dropdown-menu {
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  -webkit-border-radius: 4px;
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    -moz-border-radius: 4px;
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          border-radius: 4px;
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}
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.nav-tabs .dropdown-toggle .caret,
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.nav-pills .dropdown-toggle .caret {
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  margin-top: 6px;
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  border-top-color: #0088cc;
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  border-bottom-color: #0088cc;
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}
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.nav-tabs .dropdown-toggle:hover .caret,
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.nav-pills .dropdown-toggle:hover .caret {
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  border-top-color: #005580;
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  border-bottom-color: #005580;
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}
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.nav-tabs .active .dropdown-toggle .caret,
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.nav-pills .active .dropdown-toggle .caret {
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  border-top-color: #333333;
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  border-bottom-color: #333333;
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}
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.nav > .dropdown.active > a:hover {
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  color: #000000;
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  cursor: pointer;
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}
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.nav-tabs .open .dropdown-toggle,
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.nav-pills .open .dropdown-toggle,
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.nav > li.dropdown.open.active > a:hover {
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  color: #ffffff;
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  background-color: #999999;
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  border-color: #999999;
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}
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.nav li.dropdown.open .caret,
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.nav li.dropdown.open.active .caret,
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.nav li.dropdown.open a:hover .caret {
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  border-top-color: #ffffff;
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  border-bottom-color: #ffffff;
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  opacity: 1;
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  filter: alpha(opacity=100);
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}
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</style>
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</head>
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<body>
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<ul class="nav nav-tabs" id="myTab">
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  <li class="active" >
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    <a href="#">Home</a>
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  </li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Team">Team</a></li>
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  <li>
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    <a href="https://2012.igem.org/Team:NTU-Taida/https://igem.org/Team.cgi?year=2012&team_name=NTU-Taida">
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      Official Team Profile
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    </a>
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  </li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Project">Project</a></li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Parts">Parts Submitted to the Registry</a></li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Modeling">Modeling</a></li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Notebook">Notebook</a></li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Safety">Safety</a></li>
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  <li><a href="https://2012.igem.org/Team:NTU-Taida/Attributions">Attributions</a></li>
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</ul>
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<script>
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  !function ($) {
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  "use strict"; // jshint ;_;
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/* TAB CLASS DEFINITION
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  * ==================== */
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  var Tab = function ( element ) {
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    this.element = $(element)
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  }
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  Tab.prototype = {
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    constructor: Tab
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  , show: function () {
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      var $this = this.element
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        , $ul = $this.closest('ul:not(.dropdown-menu)')
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        , selector = $this.attr('data-target')
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        , previous
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        , $target
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        , e
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      if (!selector) {
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        selector = $this.attr('href')
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        selector = selector && selector.replace(/.*(?=#[^\s]*$)/, '') //strip for ie7
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      }
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      if ( $this.parent('li').hasClass('active') ) return
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      previous = $ul.find('.active a').last()[0]
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      e = $.Event('show', {
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        relatedTarget: previous
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      })
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      $this.trigger(e)
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      if (e.isDefaultPrevented()) return
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      $target = $(selector)
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      this.activate($this.parent('li'), $ul)
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      this.activate($target, $target.parent(), function () {
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        $this.trigger({
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          type: 'shown'
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        , relatedTarget: previous
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        })
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      })
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    }
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  , activate: function ( element, container, callback) {
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      var $active = container.find('> .active')
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        , transition = callback
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            && $.support.transition
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            && $active.hasClass('fade')
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      function next() {
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        $active
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          .removeClass('active')
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          .find('> .dropdown-menu > .active')
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          .removeClass('active')
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        element.addClass('active')
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        if (transition) {
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          element[0].offsetWidth // reflow for transition
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          element.addClass('in')
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        } else {
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          element.removeClass('fade')
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        }
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        if ( element.parent('.dropdown-menu') ) {
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          element.closest('li.dropdown').addClass('active')
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        }
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        callback && callback()
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      }
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      transition ?
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        $active.one($.support.transition.end, next) :
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        next()
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      $active.removeClass('in')
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    }
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  }
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/* TAB PLUGIN DEFINITION
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  * ===================== */
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  $.fn.tab = function ( option ) {
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      var $this = $(this)
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      if (!data) $this.data('tab', (data = new Tab(this)))
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      if (typeof option == 'string') data[option]()
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    })
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  }
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  $.fn.tab.Constructor = Tab
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/* TAB DATA-API
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  * ============ */
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      $(this).tab('show')
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}
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    e.preventDefault();
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    $(this).tab('show');
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  $('#myTab a[href="#"]').tab('show');
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</script>
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</body>
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</html>
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{{Project_Description}}
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== PepdEx: Smart Peptide-Based Therapies ==
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*Microbial biotechnology has applications in a wide spectrum of areas, from agriculture, environmental protection to biofuels. The original scheme is simple, for instance manipulate microbes to produce certain chemicals. As a medical-based team, we aim to design microbes to target human diseases. The ultimate goal is to use microbes as a general platform to do complex calculations that respond to conditions in human body, and then administer smart peptide-based therapies.<br />
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*We will first use anti-obesity as a proof-of-principle application to this approach. Non-pathogenic E. Coli will live in the intestines and serve as a device to sense the presence of fatty acids, and as an output secret synthetic GLP-1 peptide to suppress the appetite. Appropriate signal peptide and Penetratin will be used to facilitate peptide secretion and intestinal uptake, respectively. Since the intestine is a highly fluctuating environment, we will incorporate a two-filter circuit with anti-noise function, so that the system only responds to sustained stimulus. In addition, due to burden effect bacteria with artificial plasmids will be gradually lost from the population without selection pressure; plasmid segregational instability will also introduce undesirable alterations to the final function for systems encoded in multiple plasmids (as in our case). <br />
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*To circumvent this, we also incorporate plasmid stabilization modules including partition system and multimer resolution system. With this general concept we will also explore other pieces of human disease with alternative circuit designs, for instance with an oscillator circuit we can periodically deliver synthetic peptides based on natural secretory pattern or therapeutic regimen.<br />
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Latest revision as of 23:28, 26 October 2012

NTU-Taida

Retrieved from "http://2012.igem.org/Team:NTU-Taida"