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<h3home>Snifferomyces</h3home><br/>
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<font size="2" face="sans-serif">Snifferomyces is a modular system, used in the detection of volatile compounds. It has in the membrane a <b>G-protein–coupled receptor</b> that can bind to a <b>specific signal</b>, once bound it then <b>switches on a signaling machinery</b> which <b>transmits</b> this <b>information</b> over the plasma membrane and through the cell to <b>produce a Quantitative response</b> in the form of <a href="https://2012.igem.org/Team:TU-Delft/part2"><b>fluorescence</b></a>. Using the Snifferomyces, our <b>aim</b> is to develop a <b>universal olfactory system</b> which <b>allows scientists</b> to <a href="https://2012.igem.org/Team:TU-Delft/part1#A3"><b>introduce olfactory</a> receptors in yeast with minimal effort.</b>
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<b>G-protein–coupled receptors (GPCRs)</b> are one of the most important classes of proteins in living organisms that allows <b>transmission of a wide variety of signals</b> over the cell membrane, between cells and over long distances in the human body, thus acting as both the <b>gatekeepers</b> and <b>molecular messengers</b> of the cell. The importance of these receptors is emphasized by the <b>Nobel prize</b> awarded in 2004 for the discoveries of <b>"odorant receptors and the organization of the olfactory system"</b> and in 2012 for <b>"studies of G-protein–coupled receptors".</b></p>
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<ul><li><a href="https://2012.igem.org/Team:TU-Delft/part1"> Localization of receptor NR1 using FLAG </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#P7"> Activation of receptor NR1 by the ligand niacin </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part2#A2"> Activation of the reporter by the native ligand alpha pheromone</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#P8"> Providing a platform to swap receptors, promoters and terminators more easy</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/Diffusion">Device design for yeast olfactory detector</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Deterministic and stochastic simulations and property analyses of pathway model</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Data fitting for deterministic pathway model</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/StructuralModeling#A1">Prediction of a ligand-binding niche within the human niacin receptor 1 with Molecular Dynamics simulations </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach">To find stake holders and create awareness among our project, we presented our project to a very large audience by participating in several events like Llowlab on Lowlands and the Floriade.</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/HP">Our main goal is to innovate a diagnostic tool for tuberculosis, one of the major health issues in the world</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Collaboration">We have provided the iGEM Paris 2012 team two Biobricks. Together with the Amsterdam team we were able to organize a crash course on the area of synthetic biology and we were honored to attend the LIFE-symposium with the Cambrigde 2010-team.</a></li>
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<h5> Do not forget to get our app at your phone!! Stay informed about all the updates in our wiki through your android !! To download it press <a href="https://play.google.com/store/apps/details?id=com.vansteinengroentjes.apps.igem" target="_blank">here</a> </h5><br/>
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