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- | <h2 id="titleText" style="color:rgb(137,202,154);">Tsinghua-A::Modeling</h2> | + | <h2 id="titleText" style="color:rgb(137,202,154);">Tsinghua-A::<span style="color: rgb(12,117,34);">Modeling</style></h2> |
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- | <p id="2" style=" position: relative;margin-top:0px;"/> | + | <p id="2" class="jump" style=" position: absolute;margin-top:-170px;"/> |
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- | <h2 class="textTitle">Mathematical Model:DDE</h2> | + | <h2 class="textTitle" style="font-size:38px;">Mathematical Model:DDE equations</h2> |
| <div class="entry-content"> | | <div class="entry-content"> |
| <p>We construct DDE equations to describe the process of the generation of Cre protein and Cre protein binding to Loxp sites. The result shows that the concentration of Cre protein and Cre protein binding to Loxp sites grow to a peak and then degrade to zero. <a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Modeling/DDE">readmore</a></p> | | <p>We construct DDE equations to describe the process of the generation of Cre protein and Cre protein binding to Loxp sites. The result shows that the concentration of Cre protein and Cre protein binding to Loxp sites grow to a peak and then degrade to zero. <a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Modeling/DDE">readmore</a></p> |
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- | <h2 class="textTitle" style="font-size:43px;">Mathematical Model:GILLESPIE</h2> | + | <h2 class="textTitle" style="font-size:34px;">Mathematical Model:GILLESPIE algorithm</h2> |
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| <p>We use Gillespie algorithm to simulate the stochastic process of the reversal after Cre binds to Loxp sites. We can see from the result of this part that the inversion only happens when Cre protein binding to Loxp sites exists and about 50% of genes flip to the state we want.<a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Modeling/GILLESPIE">readmore</a></p> | | <p>We use Gillespie algorithm to simulate the stochastic process of the reversal after Cre binds to Loxp sites. We can see from the result of this part that the inversion only happens when Cre protein binding to Loxp sites exists and about 50% of genes flip to the state we want.<a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Modeling/GILLESPIE">readmore</a></p> |
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| <h2 class="textTitle">Sensitivity Analysis</h2> | | <h2 class="textTitle">Sensitivity Analysis</h2> |
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| <h2 class="textTitle">Feedforward</h2> | | <h2 class="textTitle">Feedforward</h2> |
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- | <h2 class="textTitle">Reference</h2> | + | <h2 class="textTitle">References</h2> |
| <div class="entry-content"> | | <div class="entry-content"> |
| <p>[1] MEGERLE J A, FRITZ G, GERLAND U, et al. Timing and dynamics of single cell gene expression in the arabinose utilization system [J]. Biophys J, 2008, 95(4): 2103-15.<br/> | | <p>[1] MEGERLE J A, FRITZ G, GERLAND U, et al. Timing and dynamics of single cell gene expression in the arabinose utilization system [J]. Biophys J, 2008, 95(4): 2103-15.<br/> |
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| <a class="navigationButtonA" href="#" style="color:rgb(137,202,154);">Introduction</a></li> | | <a class="navigationButtonA" href="#" style="color:rgb(137,202,154);">Introduction</a></li> |
- | <li class="navigationButton" id="navigationBarDetail0" style="background-color: rgb(233,244,233);height:45px;"> | + | <li class="navigationButton" id="navigationBarDetail0" style="background-color: rgb(233,244,233);height:65px;"> |
- | <a class="navigationButtonA" href="#2" style="color:rgb(137,202,154);">Mathematical Model-DDE</a></li> | + | <a class="navigationButtonA" href="#2" style="color:rgb(137,202,154);">Mathematical Model-DDE equations</a></li> |
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- | <a class="navigationButtonA" href="#3" style="color:rgb(137,202,154);">Mathematical Model-GILLESPIE</a></li> | + | <a class="navigationButtonA" href="#3" style="color:rgb(137,202,154);">Mathematical Model-GILLESPIE algorithm</a></li> |
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| <a class="navigationButtonA" href="#4" style="color:rgb(137,202,154);">Sensitivity Analysis</a></li> | | <a class="navigationButtonA" href="#4" style="color:rgb(137,202,154);">Sensitivity Analysis</a></li> |
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| <a class="navigationButtonA" href="#5" style="color:rgb(137,202,154);">Feedforward</a></li> | | <a class="navigationButtonA" href="#5" style="color:rgb(137,202,154);">Feedforward</a></li> |
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- | <a class="navigationButtonA" href="#6" style="color:rgb(137,202,154);">Reference</a></li> | + | <a class="navigationButtonA" href="#6" style="color:rgb(137,202,154);">References</a></li> |
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| </ul> | | </ul> |