Team:Goettingen

From 2012.igem.org

(Difference between revisions)
(Prototype team page)
 
(160 intermediate revisions not shown)
Line 1: Line 1:
-
<!-- *** What falls between these lines is the Alert Box!  You can remove it from your pages once you have read and understood the alert *** -->
+
{{GoettingenHeader|deu=Team:Goettingen/main_deu|eng=Team:Goettingen}}
 +
{| style="width: 900px; margin:0 0 0 0; background:none; border-spacing: 0px"
 +
| style="padding: 0pt 20px 0pt 0pt; width:630px; vertical-align:top" |
 +
__TOC__
 +
== Welcome to iGEM G&ouml;ttingen ==
 +
In November 2011, most of us heard about iGEM competition for the first time.
 +
Erik, inspired by his former colleagues' enthusiastic reports, was looking for like-minded people at his new university that
 +
were willing to organize a whole project in the field of Synthetic Biology. He described the idea of the contest to anybody willing to listen. It did not take
 +
long to find five other interested students. Thus, the so called organization task force of the first iGEM team of the University of Göttingen was formed.
 +
Luckily, the iGEM competition was already well known among the University´s professors and the team found their first supporters: Prof. Heinz
 +
Neumann, head of a work group specializing in Synthetic Biology, and Prof. Jörg Stülke from the department of General and Applied Microbiology.
 +
The next task was to find a project that was interesting as well as realizable. After a lot of back and forth due to extensive discussions, Prof.
 +
Neumann presented the perfect project: "Homing Coli"!
 +
 +
After many drawbacks, like finding a suitable laboratory to realize the project, the search for additional team members began. The new
 +
fellows were quickly found, which was the story starting point of the first iGEM team of the University of Göttingen… Below you can see our timeline.
 +
 +
[[File:Timeline.png|600px|thumb|center|The timeline of the iGEM Team Göttingen 2012. For a high resultion click on the picture.]]
 +
 +
If you are interested in the [[Team:Goettingen/iGEM|iGEM competition]], the BioBrick concept, and – most importantly – [[Team:Goettingen/Project|our project]], take a look around. Here, you will find everything
 +
you need to know about "Homing Coli" and you will have the opportunity to gather knowledge about chemotaxis in general!
 +
 +
Visit our [[Team:Goettingen/Team|team site]] to learn more about us and our supporters and advisors!
 +
And, last but not least, do not forget to check out our mascot  [[Team:Goettingen/Human_Practice/Flash_coli|Flash Coli]]! He always has some interesting stories to tell and needs YOUR help to fight the horrible phages!
 +
 +
Feel free to browse this page!
 +
 +
== Homing Coli - a short introduction ==
 +
<i>Escherichia coli</i> is a commonly used bacterial model organism. It has lots of beneficial
 +
traits, e.g. a short generation time and it can be easily manipulated. Most <i>E. coli</i>
 +
strains that are used in laboratories do not exhibit high motility. The crucial element for
 +
motility is the flagellum, which is rotated by a molecular motor within the cell wall.
 +
Consequently, these are reduced in cultivated <i>E. coli</i> strains.
 +
 +
Our goal is to create an <i>E. coli</i> strain with increased swimming motility on special agar plates. Therefore, we will overexpress regulators and parts of the <i>E. coli</i> flagellum in cultivated strains in order to enhance bacterial swimming ability. The fastest <i>E. coli</i> strains will be selected and further improved. At the same time we will then be able to create an effective motility-selection method.
 +
 +
Now, you are probably wondering what the advantage of a fast <i> E. coli</i> might be. The
 +
beneficial fast phenotype can be combined with the ability of this bacterium to sense
 +
specific compounds in their environments. Chemoreceptors enable it to move towards
 +
or along gradients of such substances. We will use PCR-based site directed mutagenesis on the <i> E. coli</i> Tar receptor. The combination of speed and chemotaxis allows
 +
us to identify <i>E. coli</i> strains, which can sense interesting compounds. Thereby, an
 +
easy method for the detection of pollutants, toxins or even tumors could be provided.
 +
 +
For detailled information see our <html><a href="https://2012.igem.org/Team:Goettingen/Project">project page</a></html>
 +
 +
[[File:Homingcoli.jpg|600px|thumb|center|<html><a href="http://jb.asm.org/content/186/22/7529.full">Clive S. Barker <i> et al. </i> (2004). Increased Motility of <i> Escherichia coli </i> by Insertion Sequence Element Integration into the Regulatory Region of the flhD Operon. Journal of Bacteriology, Vol. 186: 7529-7537.</a></html>]]
 +
 +
== Synthetic Biology ==
 +
 +
Synthetic biology is an interdisciplinary scientific area that has recently developed.
 +
It links various fields of science like biology, chemistry, physics, molecular genetics,
 +
informatics and engineering.
 +
 +
Due to this combination the relation of biological design and function can be investigated
 +
from an entirely new perspective. The previous approach was limited to the examination of
 +
a structure and its function and the attempt to explain how they correlate.
 +
Recently, the reverse strategy is applied. Biological parts are specifically designed and
 +
constructed according to a desired function. These parts are characterized by a standardized
 +
modular design that facilitates their handling. The subsequent introduction of the synthetic
 +
constructs to living cells can either cause the replacement of original cellular components
 +
or result in additional elements that act cooperatively or more or less autonomously (see fig. 1).
 +
 +
[[File:SynbioGoe.jpg|600px|thumb|center|After Nandagopaland and Elowitz (2011). A continuum of synthetic biology. Wild-type cells (<b>A</b>)
 +
can be subject to two basic types of synthetic manipulation. (<b>B</b>) Autonomous synthetic circuits, consisting of
 +
ectopic components, may be introduced into the cell. Such circuits process inputs and implement functions (red arrows)
 +
seperate from the endogenous circuitry (black). However, unknown interactions with the host cell may affect their function
 +
(purple arrows) (<b>C</b>)An alternative is to rewire (red lines) the endogenous circuits themselves to have new connectivity.
 +
(<b>D</b>) Extending this line of synthetic manipulation, synthetic circuits could be integrated into appropriately rewired
 +
endogenous circuitry to act as sensors and to implent additional functionality. Ultimate goals of this program are to be
 +
able to design and construct (<b>E</b>) synthetic circuits that can functionality replace endogenous circuits or (<b>F</b>)
 +
fully autonomous circuits that operate independently of the cellular mileu. <html><a href="http://www.its.caltech.edu/~haylab/research/SBReview2011.pdf">Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated Gene Circuits. SCIENCE, Vol. 333: 1244-1248.</a></html>]]
 +
 +
Another very important and necessary feature of biological parts is orthogonality, which means in this context that independent devices can be combined unrestrictedly.
 +
This principle derives from the area of engineering and aims to alter subsystems, without impeding others.
 +
 +
This way cells can be modified as requested, resulting in a predictable behaviour.
 +
Among others, this technique can be beneficial for the effective production of
 +
certain substances, like biofuels or antibiotics.
 +
 +
<html><center>
 +
<table bordercolor="black" border="1 px" width="600 px"><tr><td>
 +
<b>Important pages</b>:<br>
 +
<a href="https://2012.igem.org/Team:Goettingen">Home</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Team">Team</a>;
 +
<a href="https://igem.org/Team.cgi?year=2012">Official Team Profile</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Project">Project</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Parts">Parts submitted to the Registry</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Modeling">Modeling</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Notebook">Notebook</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Safety">Safety</a>;
 +
<a href="https://2012.igem.org/Team:Goettingen/Attributions">Attributions</a>
 +
</td></tr>
 +
</table>
 +
</center></html>
 +
| style="width:240px; vertical-align:top" |
<html>
<html>
-
<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
+
<h2><hr><span><b>Flash Coli</b></span></h2>
-
<div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
+
<!-- News cap end -->
-
This is a template page. READ THESE INSTRUCTIONS.
+
<embed src="http://www.patrickreinke.de/igem/motionflashcoli.swf" type="application/x-shockwave-flash"
-
</div>
+
pluginspage="http://www.macromedia.com/go/getflashplayer" wmode="transparent" height="180" width="240">
-
<div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
+
<font face="Verdana" size="-1">To explore our project with Flash Coli click
-
You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
+
<a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">here</a>.<br>
-
</div>
+
<!-- News cap -->
-
<div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
+
<h2><hr><span><b>News</b></span></h2>
-
You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace. 
+
<!-- News cap end -->
-
</div>
+
-
</div>
+
-
</html>
+
-
<!-- *** End of the alert box *** -->
+
<font align="left">
 +
<!-- News 22 end--><br><hr>
 +
<p align="left"><i>27 September 2012,</i>  <b>4 h to go!!!</b> <br>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#22">To the news</a>
 +
<br>
 +
<!-- News 22 end--><br>
 +
<br>
 +
<!-- News 21 end--><br><hr>
 +
<p align="left"><i>26 September 2012,</i>  <b>Results are online!</b> <br>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#21">To the news</a>
 +
<br>
 +
<!-- News 21 end--><br><hr> 
 +
<br>
 +
<!-- News 20 -->
 +
<p align="left"><i>25 September 2012,</i>  <b>BioBricks are on their way!</b> <br>
 +
</a>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#20">To the news</a>
 +
<br>
 +
<!-- News 20 end--><br><hr>
 +
   
 +
<!-- News 19.5 -->
 +
<p align="left"><i>22 September 2012,</i>  <b>First youtube videos are online!</b> <br>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#19.5">To the news</a>
 +
<br>
 +
<!-- News 19.5 end--><br><hr>
-
{|align="justify"
+
<!-- News 19 -->
-
|You can write a background of your team here.  Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
+
<p align="left"><i>13 September 2012,</i> <b>13 days to go!</b> <br>
-
|[[Image:Goettingen_logo.png|200px|right|frame]]
+
</p>
-
|-
+
<a href="https://2012.igem.org/Team:Goettingen/News#19">To the news</a>
-
|
+
<br>
-
''Tell us more about your project. Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+
        <!-- News 19 end--><br><hr>
-
|[[Image:Goettingen_team.png|right|frame|Your team picture]]
+
-
|-
+
-
|
+
-
|align="center"|[[Team:Goettingen | Team Goettingen]]
+
-
|}
+
-
<!--- The Mission, Experiments --->
+
          <!-- News 18 -->
 +
<p align="left"><i>07 September 2012,</i>  <b>We organized the "Legoland for Scientists" symposium at the University of Göttingen.
 +
You can read everything about it <a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Panel_Discussion">here.</a></b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#18">To the news</a>
 +
<br>
 +
        <!-- News 18 end--><br><hr>
-
{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
+
<!-- News 17 -->
-
!align="center"|[[Team:Goettingen|Home]]
+
<p align="left"><i>06 September 2012,</i>  <b>Only one day left until the information evening "Legoland for scientists"...</b> <br></a>
-
!align="center"|[[Team:Goettingen/Team|Team]]
+
</p>
-
!align="center"|[https://igem.org/Team.cgi?year=2012&team_name=Goettingen Official Team Profile]
+
<a href="https://2012.igem.org/Team:Goettingen/News#17">To the news</a>
-
!align="center"|[[Team:Goettingen/Project|Project]]
+
<br>
-
!align="center"|[[Team:Goettingen/Parts|Parts Submitted to the Registry]]
+
 
-
!align="center"|[[Team:Goettingen/Modeling|Modeling]]
+
        <!-- News 17 end--><br><hr>
-
!align="center"|[[Team:Goettingen/Notebook|Notebook]]
+
 
-
!align="center"|[[Team:Goettingen/Safety|Safety]]
+
          <!-- News 16 -->
-
!align="center"|[[Team:Goettingen/Attributions|Attributions]]
+
<p align="left"><i>30 August 2012,</i>  <b>The first version of "Flash Coli - the game" is now online. Click
 +
<a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">here.</a></b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#16">To the news</a><br>
 +
        <!-- News 16 end--><br><hr>
 +
 
 +
          <!-- News 15 -->
 +
<p align="left"><i>25 August 2012,</i>  <b>Today is the "Synthetic Biology" day in Germany!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#15">To the news</a><br>
 +
        <!-- News 15 end--><br><hr>
 +
 
 +
          <!-- News 14 -->
 +
<p align="left"><i>15 August 2012,</i>  <b>In our weekly seminar Anna presented an example for Synthetic Biology.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#14">To the news</a><br>
 +
        <!-- News 14 end--><br><hr>
 +
 
 +
          <!-- News 13 -->
 +
<p align="left"><i>08 August 2012,</i>  <b> Survey: Ready to be asked? </b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#13">To the news</a><br>
 +
        <!-- News 13 end--><br><hr>
 +
 
 +
        <!-- News 12.75 -->
 +
<p align="left"><i>01 August 2012,</i>  <b>Ali and Sandra conducted their presentations in our weekly seminar.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#12.75">To the news</a><br>
 +
        <!-- News 12.75 end--><br><hr>
 +
 
 +
        <!-- News 12.5 -->
 +
<p align="left"><i>19 August 2012,</i>  <b>Human practice task force established!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#12.5">To the news</a><br>
 +
        <!-- News 12.5 end--><br><hr>
 +
 
 +
          <!-- News 12 -->
 +
<p align="left"><i>12 July 2012,</i>  <b>In today’s weekly meeting Christian told us about the European teacher meet-up in Paris.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#12">To the news</a><br>
 +
        <!-- News 12 end--><br><hr>
 +
 
 +
      <!-- News 11.5 -->
 +
<p align="left"><i>04 July 2012,</i>  <b>Let there be light!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#11.5">To the news</a><br>
 +
        <!-- News 11.5 end--><br><hr>
 +
 
 +
          <!-- News 11 -->
 +
<p align="left"><i>28 June 2012,</i>  <b>Anna, Corinna and Erik participated in the third annual congress for strategy processes "Biotechnology 2020+".</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#11">To the news</a><br>
 +
        <!-- News 11 end--><br><hr>
 +
 
 +
      <!-- News 10.5 -->
 +
<p align="left"><i>26 June 2012,</i>  <b><i>E. coli</i> strain spurred!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#10.5">To the news</a><br>
 +
        <!-- News 10.5 end--><br><hr>
 +
 
 +
          <!-- News 10 -->
 +
<p align="left"><i>21 June 2012,</i>  <b>Our first poster is designed!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#10">To the news</a><br>
 +
        <!-- News 10 end--><br><hr>
 +
 
 +
        <!-- News 9.5 -->
 +
<p align="left"><i>13 June 2012,</i>  <b>Task: Find a human practice project!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#9.5">To the news</a><br>
 +
        <!-- News 9.5 end--><br><hr>
 +
 
 +
          <!-- News 9 -->
 +
<p align="left"><i>06 June 2012,</i>  <b>Thomas Maschner, advisor from the iGEM team of the LMU Munich, came to visit us.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#9">To the news</a><br>
 +
        <!-- News 9 end--><br><hr>
 +
 
 +
        <!-- News 8.5 -->
 +
<p align="left"><i>01 June 2012,</i>  <b>Discussion of the first lab results</b> 
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#8.5">To the news</a><br>
 +
        <!-- News 8.5 end--><br><hr>
 +
 
 +
          <!-- News 8 -->
 +
<p align="left"><i>15 May 2012,</i>  <b>The first picture of our complete team.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#8">To the news</a><br>
 +
        <!-- News 8 end--><br><hr>
 +
 
 +
          <!-- News 7 -->
 +
<p align="left"><i>11 May 2012,</i>  <b>iGEM Göttingen is in the local newspaper.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#7">To the news</a><br>
 +
        <!-- News 7 end--><br><hr>
 +
 
 +
        <!-- News 6 --> <br>
 +
<p align="left"><i>04 May 2012,</i>  <b><a href="http://www.kws.com/">KWS SAAT AG</a> is now Head Sponsor.</b>
 +
</p>
 +
<p align="left">
 +
<center><img width="150 px" src="http://www.patrickreinke.de/igem/kws.png"></center>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#6">To the news</a><br>
 +
        <!-- News 6 end--><br><hr>
 +
 
 +
        <!-- News 5 -->
 +
<p align="left"><i>02 May 2012,</i>  <b>Today Anna presented our iGEM logo.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#5">To the news</a><br>
 +
        <!-- News 5 end--><br><hr>
 +
 
 +
        <!-- News 4 -->
 +
<p align="left"><i>30 April 2012,</i>  <b>We inspect the laboratory at the Max Planck campus.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#4">To the news</a><br>
 +
        <!-- News 4 end--><br><hr>
 +
 
 +
        <!-- News 3 -->
 +
<p align="left"><i>26 April 2012,</i>  <b>Weekly meeting: PCR-Lecture from Heinz.</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#3">To the news</a><br>
 +
        <!-- News 3 end--><br><hr>
 +
 
 +
        <!-- News 2 -->
 +
<p align="left"><i>19 April 2012,</i>  <b>The iGEM team Göttingen 2012 is now complete!</b>
 +
</p>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#2">To the news</a><br>
 +
        <!-- News 2 end--><br><hr>
 +
 
 +
        <!-- News 1 -->  <br>
 +
<p><i>04 April 2012,</i>    <b> <a href="http://www.sartorius.com/">Sartorius Stedim Biotech GmbH</a> is now Premium Sponsor.</b>
 +
</p>
 +
<p>
 +
<center><img width="240 px" src="http://www.patrickreinke.de/igem/sartorius.png"></center>
 +
<a href="https://2012.igem.org/Team:Goettingen/News#1">To the news</a><br><br><hr>
 +
        <!-- News 1 end-->
 +
</font>
 +
</html>
|}
|}
 +
{{GoettingenFooter}}

Latest revision as of 01:02, 27 September 2012

Deutsch  / English 

Contents

Welcome to iGEM Göttingen

In November 2011, most of us heard about iGEM competition for the first time. Erik, inspired by his former colleagues' enthusiastic reports, was looking for like-minded people at his new university that were willing to organize a whole project in the field of Synthetic Biology. He described the idea of the contest to anybody willing to listen. It did not take long to find five other interested students. Thus, the so called organization task force of the first iGEM team of the University of Göttingen was formed.

Luckily, the iGEM competition was already well known among the University´s professors and the team found their first supporters: Prof. Heinz Neumann, head of a work group specializing in Synthetic Biology, and Prof. Jörg Stülke from the department of General and Applied Microbiology. The next task was to find a project that was interesting as well as realizable. After a lot of back and forth due to extensive discussions, Prof. Neumann presented the perfect project: "Homing Coli"!

After many drawbacks, like finding a suitable laboratory to realize the project, the search for additional team members began. The new fellows were quickly found, which was the story starting point of the first iGEM team of the University of Göttingen… Below you can see our timeline.

The timeline of the iGEM Team Göttingen 2012. For a high resultion click on the picture.

If you are interested in the iGEM competition, the BioBrick concept, and – most importantly – our project, take a look around. Here, you will find everything you need to know about "Homing Coli" and you will have the opportunity to gather knowledge about chemotaxis in general!

Visit our team site to learn more about us and our supporters and advisors! And, last but not least, do not forget to check out our mascot Flash Coli! He always has some interesting stories to tell and needs YOUR help to fight the horrible phages!

Feel free to browse this page!

Homing Coli - a short introduction

Escherichia coli is a commonly used bacterial model organism. It has lots of beneficial traits, e.g. a short generation time and it can be easily manipulated. Most E. coli strains that are used in laboratories do not exhibit high motility. The crucial element for motility is the flagellum, which is rotated by a molecular motor within the cell wall. Consequently, these are reduced in cultivated E. coli strains.

Our goal is to create an E. coli strain with increased swimming motility on special agar plates. Therefore, we will overexpress regulators and parts of the E. coli flagellum in cultivated strains in order to enhance bacterial swimming ability. The fastest E. coli strains will be selected and further improved. At the same time we will then be able to create an effective motility-selection method.

Now, you are probably wondering what the advantage of a fast E. coli might be. The beneficial fast phenotype can be combined with the ability of this bacterium to sense specific compounds in their environments. Chemoreceptors enable it to move towards or along gradients of such substances. We will use PCR-based site directed mutagenesis on the E. coli Tar receptor. The combination of speed and chemotaxis allows us to identify E. coli strains, which can sense interesting compounds. Thereby, an easy method for the detection of pollutants, toxins or even tumors could be provided.

For detailled information see our project page

Clive S. Barker et al. (2004). Increased Motility of Escherichia coli by Insertion Sequence Element Integration into the Regulatory Region of the flhD Operon. Journal of Bacteriology, Vol. 186: 7529-7537.

Synthetic Biology

Synthetic biology is an interdisciplinary scientific area that has recently developed. It links various fields of science like biology, chemistry, physics, molecular genetics, informatics and engineering.

Due to this combination the relation of biological design and function can be investigated from an entirely new perspective. The previous approach was limited to the examination of a structure and its function and the attempt to explain how they correlate. Recently, the reverse strategy is applied. Biological parts are specifically designed and constructed according to a desired function. These parts are characterized by a standardized modular design that facilitates their handling. The subsequent introduction of the synthetic constructs to living cells can either cause the replacement of original cellular components or result in additional elements that act cooperatively or more or less autonomously (see fig. 1).

After Nandagopaland and Elowitz (2011). A continuum of synthetic biology. Wild-type cells (A) can be subject to two basic types of synthetic manipulation. (B) Autonomous synthetic circuits, consisting of ectopic components, may be introduced into the cell. Such circuits process inputs and implement functions (red arrows) seperate from the endogenous circuitry (black). However, unknown interactions with the host cell may affect their function (purple arrows) (C)An alternative is to rewire (red lines) the endogenous circuits themselves to have new connectivity. (D) Extending this line of synthetic manipulation, synthetic circuits could be integrated into appropriately rewired endogenous circuitry to act as sensors and to implent additional functionality. Ultimate goals of this program are to be able to design and construct (E) synthetic circuits that can functionality replace endogenous circuits or (F) fully autonomous circuits that operate independently of the cellular mileu. Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated Gene Circuits. SCIENCE, Vol. 333: 1244-1248.

Another very important and necessary feature of biological parts is orthogonality, which means in this context that independent devices can be combined unrestrictedly. This principle derives from the area of engineering and aims to alter subsystems, without impeding others.

This way cells can be modified as requested, resulting in a predictable behaviour. Among others, this technique can be beneficial for the effective production of certain substances, like biofuels or antibiotics.

Important pages:
Home; Team; Official Team Profile; Project; Parts submitted to the Registry; Modeling; Notebook; Safety; Attributions

Flash Coli

To explore our project with Flash Coli click here.

News


27 September 2012, 4 h to go!!!

To the news



26 September 2012, Results are online!

To the news


25 September 2012, BioBricks are on their way!

To the news

22 September 2012, First youtube videos are online!

To the news

13 September 2012, 13 days to go!

To the news

07 September 2012, We organized the "Legoland for Scientists" symposium at the University of Göttingen. You can read everything about it here.

To the news

06 September 2012, Only one day left until the information evening "Legoland for scientists"...

To the news

30 August 2012, The first version of "Flash Coli - the game" is now online. Click here.

To the news

25 August 2012, Today is the "Synthetic Biology" day in Germany!

To the news

15 August 2012, In our weekly seminar Anna presented an example for Synthetic Biology.

To the news

08 August 2012, Survey: Ready to be asked?

To the news

01 August 2012, Ali and Sandra conducted their presentations in our weekly seminar.

To the news

19 August 2012, Human practice task force established!

To the news

12 July 2012, In today’s weekly meeting Christian told us about the European teacher meet-up in Paris.

To the news

04 July 2012, Let there be light!

To the news

28 June 2012, Anna, Corinna and Erik participated in the third annual congress for strategy processes "Biotechnology 2020+".

To the news

26 June 2012, E. coli strain spurred!

To the news

21 June 2012, Our first poster is designed!

To the news

13 June 2012, Task: Find a human practice project!

To the news

06 June 2012, Thomas Maschner, advisor from the iGEM team of the LMU Munich, came to visit us.

To the news

01 June 2012, Discussion of the first lab results

To the news

15 May 2012, The first picture of our complete team.

To the news

11 May 2012, iGEM Göttingen is in the local newspaper.

To the news


04 May 2012, KWS SAAT AG is now Head Sponsor.

To the news

02 May 2012, Today Anna presented our iGEM logo.

To the news

30 April 2012, We inspect the laboratory at the Max Planck campus.

To the news

26 April 2012, Weekly meeting: PCR-Lecture from Heinz.

To the news

19 April 2012, The iGEM team Göttingen 2012 is now complete!

To the news


04 April 2012, Sartorius Stedim Biotech GmbH is now Premium Sponsor.

To the news

↑ Back to top!

Retrieved from "http://2012.igem.org/Team:Goettingen"