Team:Paris Bettencourt

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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
 
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<div style="position:absolute;left:15px;top:255px;z-index:100"><img src=https://static.igem.org/mediawiki/2012/0/04/New_PB2012.png width="50"> <sub>This sign indicating new results after the European Jamboree.</sub></div>
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<div id="grouptitle">How Safe is Safe Enough?</div>
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Synthetic biologists, and iGEM teams in particular, design Genetically Engineered Organisms (GEOs) to benefit people and communities around the world. However, many proposed applications necessarily involve the deployment of GEOs in natural environments. These dreams can never be made real without technical, legal and ethical guidelines for the use of GEOs outside the lab. Our project addresses this serious need from our perspective as safety bioengineers, citizens and humans.
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<br><br>  We have developed the <b>bWARE containment module</b> to substantially reduce the risk of Horizontal Gene Trasfer (HGT) while remaining compatible with existing iGEM devices. A GEO may first perform its beneficial function during a programmed delay. Then our system activates, irreversibly degrading DNA throughout the population, leaving no genetic information behind. Multiple cooperative systems provide redundancy against inevitable mutations or external stresses.
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|During previous years’ competitions, many iGEM teams have developed projects that propose the application of Genetically Engineered Organisms (GEO) in natural environments. However, issues of biosafety continue to complicate and constrain the use of GEOs outside the lab. A primary concern is the Horizontal Gene Transfer (HGT) of synthetic genes to natural popultations. Various strategies have been developed to address this problem, providing varying levels of containment. However, the substantial elimination of HGT risks remains difficult or perhaps impossible.
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<br><br><b>Human practice considerations</b> influenced every stage of our design process. Given different biosafety modules that may be used singly or in combination, what are the best practices for associating specific safety systems with specific applications? Given that no biosafety system can completely eliminate the risk of HGT, how safe is safe enough? Who should decide when the benefits of GEOs outweigh the risks, and what information do they need? We have collected and indexed existing iGEM biosafety projects. We have engaged expert and public opinion to develop a new proposal for qualitative and quantitatve documentation of BioBrick safety devices.
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<br><br>  Biosafety is an exciting design challenge, an essential enabling technology for synthetic biology, and a fundamental ethical obligation of all bioengineers. We expect that modular containment systems like bWARE will be standard ware in the next generation of iGEM projects.
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Our project aims to :
 
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- Evaluate the risk of HGT in different SynBio applications
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<br><br><br>
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<iframe align="center" width="600" height="400" src="https://www.youtube.com/embed/iyynMAQ-fjY?rel=0" frameborder="0" allowfullscreen style="z-index:100"></iframe>
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- Develop a new, improved containment system to expand the range of environments where GEOs can be used safely.
 
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To do so, we will rely on three levels of containment :
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- Physical containment with alginate capsules
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- Semantic containment using an amber supressor system
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- An improved killswitch featuring delayed population-level suicide through complete genome degradation.
 
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<img src=https://static.igem.org/mediawiki/2012/e/e0/ParisB_Medal.gif width=15><sub><b>World Championship 2nd Runner Up</b></sub> <br> <br>
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<img src=https://static.igem.org/mediawiki/2012/e/e0/ParisB_Medal.gif width=15><sub><b>World Championship Best Environment Project</b></sub> <br> <br>
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<img src=https://static.igem.org/mediawiki/2012/e/e0/ParisB_Medal.gif width=15><sub>European Jamboree Gold Medal</sub> <br>  <br> 
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<img src=https://static.igem.org/mediawiki/2012/e/e0/ParisB_Medal.gif width=15><sub>European Jamboree Safety Commendation</sub>
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<br> <br>
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<h3>Go to</h3><br>
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<center><a href=https://2012.igem.org/Team:Paris_Bettencourt/Achievements> <img src=https://static.igem.org/mediawiki/2012/0/0c/ParisB_achievement_icon.png width=150></a></center>
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<center><a href=https://2012.igem.org/Team:Paris_Bettencourt/Overview> <img src=https://static.igem.org/mediawiki/2012/e/e8/ParisB_project_icon.png width=150></a></center>
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<center><a href=https://2012.igem.org/Team:Paris_Bettencourt/Human_Practice/Frontpage> <img src=https://static.igem.org/mediawiki/2012/0/05/ParisB_human_icon.png width=150></a></center>
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<center><a href=https://2012.igem.org/Team:Paris_Bettencourt/Modeling> <img src=https://static.igem.org/mediawiki/2012/8/82/ParisB_Assessment.png width=150></a></center>
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<li class="first"><span class="date" style="background:rgb(121,173,89);">9/7/12</span> Regional Jamboree attendance fee due</li>
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<li><span class="date" style="background:rgb(121,173,89);">9/7/12</span> <a href="/Judging/Track_Selection">Track selection due </a></li>
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<li class="last"><span class="date">9/26/12</span>Project and part documentation due, including documentation for all medal criteria </li>
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<li class="last"><span class="date" style="background:rgb(121,173,89);">9/26/12</span>BioBrick Part DNA due to the Registry </li>
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<li class="last"><span class="date">9/26/12</span>Wiki FREEZE at 11:59pm, EDT </li>
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<li class="last"><span class="date">10/5-7/12</span>iGEM 2012 Regional Jamborees</li>
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<li class="last"><span class="date">11/2-5/12</span>iGEM 2012 World Championship Jamboree, MIT</li>
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<h3>Quick Links</h3>
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<li class="first"><a href="https://2012.igem.org">iGEM 2012</a></li>
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<li class="first"><a href="http://partsregistry.org/Main_Page">Parts Registry</a></li>
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<li class="first"><a href="http://www.cri-paris.org/en/cri/">The Center for Research and Interdisciplinarity</a></li>
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We will strive to make our system as robust against mutations as possible.
 
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|align="center"|[[Team:Paris_Bettencourt | Team Paris_Bettencourt]]
 
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!align="center"|[[Team:Paris_Bettencourt|Home]]
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!align="center"|[[Team:Paris_Bettencourt/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2012&team_name=Paris_Bettencourt Official Team Profile]
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!align="center"|[[Team:Paris_Bettencourt/Project|Project]]
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!align="center"|[[Team:Paris_Bettencourt/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Paris_Bettencourt/Modeling|Modeling]]
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!align="center"|[[Team:Paris_Bettencourt/Notebook|Notebook]]
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!align="center"|[[Team:Paris_Bettencourt/Safety|Safety]]
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!align="center"|[[Team:Paris_Bettencourt/Attributions|Attributions]]
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Latest revision as of 19:20, 9 November 2012


iGEM Paris Bettencourt 2012

This sign indicating new results after the European Jamboree.


How Safe is Safe Enough?

Synthetic biologists, and iGEM teams in particular, design Genetically Engineered Organisms (GEOs) to benefit people and communities around the world. However, many proposed applications necessarily involve the deployment of GEOs in natural environments. These dreams can never be made real without technical, legal and ethical guidelines for the use of GEOs outside the lab. Our project addresses this serious need from our perspective as safety bioengineers, citizens and humans.

We have developed the bWARE containment module to substantially reduce the risk of Horizontal Gene Trasfer (HGT) while remaining compatible with existing iGEM devices. A GEO may first perform its beneficial function during a programmed delay. Then our system activates, irreversibly degrading DNA throughout the population, leaving no genetic information behind. Multiple cooperative systems provide redundancy against inevitable mutations or external stresses.

Human practice considerations influenced every stage of our design process. Given different biosafety modules that may be used singly or in combination, what are the best practices for associating specific safety systems with specific applications? Given that no biosafety system can completely eliminate the risk of HGT, how safe is safe enough? Who should decide when the benefits of GEOs outweigh the risks, and what information do they need? We have collected and indexed existing iGEM biosafety projects. We have engaged expert and public opinion to develop a new proposal for qualitative and quantitatve documentation of BioBrick safety devices.

Biosafety is an exciting design challenge, an essential enabling technology for synthetic biology, and a fundamental ethical obligation of all bioengineers. We expect that modular containment systems like bWARE will be standard ware in the next generation of iGEM projects.






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