Team:Tsinghua-A/Project/Motivation

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">Abstruct</span></h2>
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     <h2 class="textTitle" style="margin-top:135px;">Background</h2>
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<p>In the development of biosynthesis, numerous logic pathways have been designed to fullfil certain functions. However, all these imaginative designs lack an important feature ---- once they are designed, no further alter can be done to the unit, which makes it difficult to be applied as fundamental units to large-scale complex systems.</p>
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<h2>Inspiration</h2>
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<p> Since many of us frequently deal with complex electric circuits, we get inspiration from an electronic component, PLD, to solve this problem.</br>
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A PLD or programmable logic device is used to build reconfigurable digital circuits. Unlike a logic gate, which has a fixed function, a PLD has an undefined function at the time of manufacture. Before the PLD can be used in a circuit it must be programmed, that is, reconfigured.</br>
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As is the fact, PLD serves as a milestone in the progress of digital technology and is now
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widespread in digital logic experiments. Thus we were motivated to apply it in cells and make  
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logic-flexible, in another word, programmable gene circuits.
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<p>Since the Programmable Logic Device has played a significant role in the progress of digital technology, we were motivated to apply it in cells to build  gene circuits, which means the logic inside cells can be changed up to the external stimulus we’ve given beforehand. We name it CPLD, which is short for Cell-based Programmable Logic Device.<a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Project/Motivation">readmore</a></p>
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<a href="https://2012.igem.org/Team:Tsinghua-A/Project" style="margin-left:40px;font-size:20px;">Return</a>
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    <h2 class="textTitle" >Design</h2>
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<p>'Life' is too big a word, especially when we are talking about synthetic biology, but we still find it interesting, in our life, when everyone meets alternatives and makes his decisions, that colorful behaviors and lifestyles just differentiate from small left-or-right choices, and that widely-differed ones make up a well-operated society. This year our study will be concentrated on controllable choice-making E. Coli, with left-or-right directions of gene expression to be determined, thus to realize the life-like differentiation and dedifferentiation, and synthesized function of the cell 'teamwork'. That's the idea why we named our project after 'E. CoLIFE'.<a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Project/Design">readmore</a></p>
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<p>We can transform AND gate into OR gate through a flip of the sequence between opposite loxP sites. Moreover, based on a similar idea, our system shows a strong scalability in further design.<a class="textLink" href="https://2012.igem.org/Team:Tsinghua-A/Project/Scalability">readmore</a></p>
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Latest revision as of 20:26, 26 October 2012

Tsinghua-A::Project::Abstruct

Background

In the development of biosynthesis, numerous logic pathways have been designed to fullfil certain functions. However, all these imaginative designs lack an important feature ---- once they are designed, no further alter can be done to the unit, which makes it difficult to be applied as fundamental units to large-scale complex systems.

Inspiration

Since many of us frequently deal with complex electric circuits, we get inspiration from an electronic component, PLD, to solve this problem.
A PLD or programmable logic device is used to build reconfigurable digital circuits. Unlike a logic gate, which has a fixed function, a PLD has an undefined function at the time of manufacture. Before the PLD can be used in a circuit it must be programmed, that is, reconfigured.
As is the fact, PLD serves as a milestone in the progress of digital technology and is now widespread in digital logic experiments. Thus we were motivated to apply it in cells and make logic-flexible, in another word, programmable gene circuits.

Return



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