Team:TU-Delft/Team2

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<html><head><title>TU-Delft Team page 2012</title></head>
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<title>TUDelft -Leiden iGEM 2012</title>
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<table  style="border:5px solid green;">
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<h2 align="center">Students</h2>
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<td style="font-size:100%;">
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<strong style="font-size:120%;">Snifferomyces:Yeast with a sense of smell</strong>
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<p>The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!</p>
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    <td ><font face="Georgia">
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Lizah" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/a/a3/RLizah.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Lizah" target="_blank"><strong>Lizah van der Aart</strong></a>
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<br/><b>Background:</b><br/>Bsc Biology<br/>
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<b>Main Task:</b><br/> Lab/Funding/Graphics
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Sietske" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/a/a4/Rsietske.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Sietske" target="_blank"><strong>Sietske Grijseels</strong></a>
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<br/><b>Background:</b><br/>Bsc Life Sciences<br/>
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<b>Main Task:</b><br/> Lab/Human Practise/Social Chair
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Isabelle" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/6/6a/Risabelle2.jpg" width="160" height="200" align="left" valign="top"/></a>
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<br/><a href="https://2012.igem.org/Team:TU-Delft/Team/Isabelle" target="_blank"><strong>Isabelle Jacobs</strong></a>
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<br/><b>Background:</b><br/>Bsc Maritime Engineering<br/>
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<b>Main Task:</b><br/>Funding/Outreach/PR
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Marcel" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/3/3e/Rmarcel.jpg" width="160" height="200" align="left" valign="top"/></a>
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<br/><a href="https://2012.igem.org/Team:TU-Delft/Team/Marcel" target="_blank"><strong>Marcel Langelaan</strong></a>
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<br/><b>Background:</b><br/>Msc Applied Physics
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<br/><b>Main Task:</b><br/>Lab/Safety/Modelling
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Stephanie" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/2/2f/Rstephanie2.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Stephanie" target="_blank"><strong>Stephanie Lubbers</strong></a>
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<br/><b>Background:</b><br/> Bsc Aerospace Engineering<br/>
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<b>Main Task:</b><br/> Team manager/Human Practise
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Lakshmeesh" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/0/08/Rlakshmeesh.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Lakshmeesh" target="_blank"><strong>Lakshmeesh Mohre Maruthi</strong></a>
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<br/><b>Background:</b><br/> Msc Systems and Control<br/>
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<b>Main Task:</b><br/> Modelling/PR
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Yifan" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/b/ba/Ryifan2.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Yifan" target="_blank"><strong>Yifan Pan</strong></a>
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<br/><b>Background:</b><br/>Msc Systems and Control<br/>
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<b>Main Task:</b><br/> Modelling/Collaboration
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Eftychia" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/7/7e/Reftychia2.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Eftychia" target="_blank"><strong>Eftychia Thomaidou</strong></a>
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<br/><b>Background:</b><br/>Msc Bioinformatics<br/>
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<b>Main Task:</b><br/> Wiki/Modelling
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Mark" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/3/35/Rmark2.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Mark" target="_blank"><strong>Mark Weijers</strong></a>
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<br/><b>Background:</b><br/>Msc Biochemical Engineering<br/>
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<b>Main Task:</b><br/> Science/Outreach
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Menno" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/f/f3/Rmenno.jpg" width="160" height="200" align="left" valign="top"/></a>
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Menno" target="_blank"><strong>Menno Witteveen</strong></a>
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<br/><b>Background:</b><br/>Msc Chemical Engineering<br/>
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<b>Main Task:</b><br/> Science/Funding
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<h2 align="center">Supervisors</h2>
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<p style="color:#2ab117; background-color:gold;" ><strong><center> Advanced to the World Championship Jamboree!! </center></strong></p>
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<table width="100%cellspacing="0" cellpadding="0">  
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<br/>
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<h2><i>Snifferomyces</i>: A Tuberculosis Screening Automaton</h2>
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<center>
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<img src="https://static.igem.org/mediawiki/igem.org/8/83/G3961.png"  width="600" />
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</center>
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<p>The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!</p>
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<hr/>
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<br/>
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<img src="https://static.igem.org/mediawiki/igem.org/f/fd/Achievementlink.jpg" name="kugroup" width="300"  border="0" id="kugroup" />
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<ul><li><a href="https://2012.igem.org/Team:TU-Delft/part1"> Localization of receptor NR1 using FLAG </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#P7"> Activation of receptor NR1 by the ligand niacin </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part2#A2"> Activation of the reporter by the native ligand alpha pheromone</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#P8"> Providing a platform to swap receptors, promoters and terminators more easy</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/Diffusion">Device design for yeast olfactory detector</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Deterministic and stochastic simulations and property analyses of pathway model</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/SingleCellModel">Data fitting for deterministic pathway model</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Modeling/StructuralModeling#A1">Prediction of a ligand-binding niche within the human niacin receptor 1 with Molecular Dynamics simulations </a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach">To find stake holders and create awareness among our project, we presented our project to a very large audience by participating in several events like Llowlab on Lowlands and the Floriade.</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/HP">Our main goal is to innovate a diagnostic tool for tuberculosis, one of the major health issues in the world</a></li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/Collaboration">We have provided the iGEM Paris 2012 team two Biobricks. Together with the Amsterdam team we were able to organize a crash course on the area of synthetic biology and we were honored to attend the LIFE-symposium with the Cambrigde 2010-team.</a></li>
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</ul>
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<hr/>
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<center><iframe src="http://www.thenewview.eu/igem/wiki/photos/photoslide.html" style="width:580px; height:330px; border:0;"></iframe></center>
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<h2>Project Abstract</h2>
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<p>The aim of this yearӳ iGEM project will be the synthesis of <b>an olfactory device for the purpose of characterization of volatile compound</b>. Here, the aim is to introduce <a href="https://2012.igem.org/Team:TU-Delft/part1#A3">olfactory receptor gene fusions</a> into Saccharomyces cerevisiae and linking these receptors to a <a href="https://2012.igem.org/Team:TU-Delft/part2#A3">transcription response</a>. Aims:
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<ol type="I">
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<li>The diagnostics of the presence of tuberculosis bacteria in the lungs by sensing chemical compound methyl nicotinate by S. cerevisiae. For diagnostics, the response to these molecules is light, generated by the Lux proteins (visible blue light) or <a href="https://2012.igem.org/Team:TU-Delft/part2">GFP (fluorescent green)</a>.</li>
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#A3">Introducing receptors</a> for sensing the presence of banana-smell (iso-amyl acetate). This is done to see whether communication between S. cerevisiae and E. coli is possible by this volatile intermediate.</li>
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<li>Supplying a toolkit which allows scientists to <a href="https://2012.igem.org/Team:TU-Delft/part1#A3">introduce olfactory receptors</a> in yeast with minimal effort. Further we want to characterize the receptor parts submitted by the <a href="https://2009.igem.org/Team:HKU-HKBU">2009 Hongkong university</a>.</li>
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</ol>
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</p>
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<hr/>
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<h5>Yes! We are at the <em>National News</em>!!! You can read the article from <b>NRC Handelsblad</b> <a href="https://static.igem.org/mediawiki/igem.org/c/c7/ZomerrepoNRC7aug.pdf">here</a>! <br/>
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  But this is not enough. We really need your enhancement in order to succeed to our effort. Please help us improve our world! You can find more information in our <b><a href="https://2012.igem.org/Team:TU-Delft/crowdfunding">Crowdfunding Page</a></b></h5>
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<hr/>
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<center>
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<div id="groupphoto" style="position:relative; top:0; left:0;  width:580px; height:400px; border:0; margin:0 0 20px 0; padding:0; overflow:hidden;">
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<a href="https://static.igem.org/mediawiki/igem.org/7/7b/Groupphoto2.PNG" rel="lightbox" title="iGem TUDelft Leiden team 2012" target="_blank">
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<img src="https://static.igem.org/mediawiki/igem.org/7/7b/Groupphoto2.PNG" name="kugroup" width="580" height="400" border="0" id="kugroup" /></a></div><br/>
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</center>
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<hr/>
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<h5> Do not forget to get our app at your phone!! Stay informed about all the updates in our wiki through your android !! To download it press <a href="https://play.google.com/store/apps/details?id=com.vansteinengroentjes.apps.igem" target="_blank">here</a> </h5><br/>
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<h6>You can also find us on <a href="https://www.facebook.com/TudelftIgem2012">facebook</a>! </h6>
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<hr/>
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<div id="clustrmaps-widget"></div><script type="text/javascript">var _clustrmaps = {'url' : 'https://2012.igem.org/Team:TU-Delft', 'user' : 1038920, 'server' : '4', 'id' : 'clustrmaps-widget', 'version' : 1, 'date' : '2012-08-25', 'lang' : 'en', 'corners' : 'square' };(function (){ var s = document.createElement('script'); s.type = 'text/javascript'; s.async = true; s.src = 'http://www4.clustrmaps.com/counter/map.js'; var x = document.getElementsByTagName('script')[0]; x.parentNode.insertBefore(s, x);})();</script><noscript><a href="http://www4.clustrmaps.com/user/155fda48"><img src="http://www4.clustrmaps.com/stats/maps-no_clusters/2012.igem.org-Team-TU-Delft-thumb.jpg" alt="Locations of visitors to this page" /></a></noscript></div>
   
   
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Anne" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/2/26/Anne2.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Anne" target="_blank"><strong>Anne Meyer</strong></a>
 
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<br/>
 
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<b>Field:</b><br/>Biochemistry and Cell Biology<br/>
 
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</font></td>
 
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    <td  ><font face="Georgia">
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Esengul" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/a/a4/Resengul.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Esengul" target="_blank"><strong>Esengül Yildirim</strong></a>
 
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<br/>
 
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<b>Field:</b><br/>Molecular Biology<br/>
 
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</font></td>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Alessandro" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/b/b9/Alessandro3.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Alessandro" target="_blank"><strong>Alessandro Abate</strong></a>
 
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<br/>
 
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<b>Field:</b><br/>Systems Theory<br/>
 
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<br/><br/>
 
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<h2 align="center">Advisors</h2>
 
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<table width="100%"  cellspacing="0" cellpadding="0">
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Emrah" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/2/2b/Emrah.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<br/><a href="https://2012.igem.org/Team:TU-Delft/Team/Emrah" target="_blank"><strong>Emrah Nikerel</strong></a>
 
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<br/><b>Field:</b><br/>Metabolic engineering, Systems biology, Bioinformatics<br/>
 
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</font></td>
 
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    <td  ><font face="Georgia">
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Aljoscha" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/f/f1/Aljoscha.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Aljoscha" target="_blank"><strong>Aljoscha Wahl</strong></a>
 
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<br/><b>Field:</b><br/>Metabolic Systems Engineering<br/>
 
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</font></td>
 
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</tr>
 
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    <td  ><font face="Georgia">
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Ilya" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/c/c3/Rilya.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Ilya" target="_blank"><strong>Ilya Tkachev</strong></a>
 
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<br/><b>Field:</b><br/>Systems Theory<br/>
 
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</font></td>
 
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    <td  ><font face="Georgia">
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Calin" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/3/39/RCalin2.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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<a href="https://2012.igem.org/Team:TU-Delft/Team/Calin" target="_blank"><strong>Calin Plesa</strong></a>
 
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<br/><b>Field:</b><br/>BioNanoScience<br/>
 
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</font></td>
 
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  <a href="https://2012.igem.org/Team:TU-Delft/Team/Daniel" target="_blank"><img src="https://static.igem.org/mediawiki/igem.org/5/5a/RDaniel2.jpg" width="160" height="200" align="left" valign="top"/></a>
 
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  <a href="https://2012.igem.org/Team:TU-Delft/Team/Daniel" target="_blank"><strong>Daniel Solis Escalante</strong></a>
 
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  <br/><b>Field:</b><br/>Industrial Microbiology<br/>
 
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Revision as of 09:32, 26 October 2012

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TUDelft -Leiden iGEM 2012
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Snifferomyces:Yeast with a sense of smell

The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!


Advanced to the World Championship Jamboree!!


Snifferomyces: A Tuberculosis Screening Automaton


The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!




Project Abstract

The aim of this yearӳ iGEM project will be the synthesis of an olfactory device for the purpose of characterization of volatile compound. Here, the aim is to introduce olfactory receptor gene fusions into Saccharomyces cerevisiae and linking these receptors to a transcription response. Aims:

  1. The diagnostics of the presence of tuberculosis bacteria in the lungs by sensing chemical compound methyl nicotinate by S. cerevisiae. For diagnostics, the response to these molecules is light, generated by the Lux proteins (visible blue light) or GFP (fluorescent green).
  2. Introducing receptors for sensing the presence of banana-smell (iso-amyl acetate). This is done to see whether communication between S. cerevisiae and E. coli is possible by this volatile intermediate.
  3. Supplying a toolkit which allows scientists to introduce olfactory receptors in yeast with minimal effort. Further we want to characterize the receptor parts submitted by the 2009 Hongkong university.


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