Team:TU-Delft/Modeling

From 2012.igem.org

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<head><title>Human Outreach</title></head>
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<img src="https://static.igem.org/mediawiki/igem.org/7/74/Background_greenlamp.jpg" class="bg_team"></img>
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<div id="logo_ed"><a href="https://2012.igem.org/Team:TU-Delft" 'onfocus=this.blur()'><img src="https://static.igem.org/mediawiki/igem.org/e/e2/Igemlogo.png" border="0" width="100" height="100"></a></div>
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= Modeling =
 
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Mathematical models in biology like in every other field, is a description of a system using mathematical concepts and language. Models have become indispensable tools, aiding researchers express their scientific knowledge. We decided to use the modeling expertise of the team members to achieve three key objectives for this years project.
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* Develop scientific understanding of the yeast pheromone response pathway.
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<h2>Human Outreach</h2>
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* Test the effects of the changes to the system.
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* Aid decision making in the laboratory.
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<p> Our aim in Human Outreach was to spread our word among a broad audience. We invested a lot of time and effort but we have been rewarded with many opportunities. Frank Theys is making a documentary about us and a few other laboratories. We were invited to discuss our project at the Life Symposium. We educated children at the Floriade and at the Nacht van de Kunst & Wetenschap. We discussed and explained our project at Llowlab, part of Lowlands, to (young) adults with many different backgrounds. So these past few months many interesting, critical and curious people crossed our path and we have been delighted to educate them and discuss our project with them.
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<br/><br/>Click on the photo to see a more detailed project description </p>
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<table id="Projects">
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<th><h6>Floriade<h6/></th>
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<th><h6>Documentary<h6/></th>
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<th><h6>Nacht van de Kunst en Wetenschap<h6/></th>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/Floriade" target="_blank">
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<img src="https://static.igem.org/mediawiki/igem.org/3/3f/TU_Delft_iGEM_2012_-_Floriade_-_Smelling_Game.jpg" height="70" width="90"/></a></td>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/Documentary" target="_blank">
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<img src="https://static.igem.org/mediawiki/igem.org/3/31/5008372.jpg" height="70" width="80"/></a></td>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/NachtvandeKW" target="_blank">
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<img src="https://static.igem.org/mediawiki/igem.org/e/e6/NachtvanKW.JPG
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To achieve the stated objectives, three different models were built encompassing the different aspects of the project.
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<th><h6>Life Symposium<h6/></th>
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<th><h6>Lowlands - Llowlab<h6/></th>
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<td><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/LifeSymposium" target="_blank">
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  <img src="https://static.igem.org/mediawiki/igem.org/1/17/LifeSymposium.png
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<td><a href="https://2012.igem.org/Team:TU-Delft/HumanOutreach/Llowlab" target="_blank">
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<img src="https://static.igem.org/mediawiki/igem.org/6/6f/LLowlab_Logo_Groen_Zwart.jpg" height="70" width="80"/></a></td>
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== Diffusion Model ==
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<img src="https://static.igem.org/mediawiki/igem.org/3/37/Footer_2.jpg" align="middle" width="690"></img>
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<a href='https://2012.igem.org/Main_Page' target="_blank"><div id='logo_igem2'></div><a/> </body></html>
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== Bio-Chemical Model ==
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The bio-chemical model was developed based on a scheme favouring the temporal order of the processes, which involved the four fundamental modules,
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* Receptor Activation
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* G - Protein Cycle
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* MAPK Cascade
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* Gene Expression
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The dynamics of the system are described using a set of differential equations governing the concentration changes of individual components and of complexes over time. On account of the gene expression module being noisy, a stochastic model of the gene expression module was implemented using stochastic differential equations. Sensitivity and stability analysis were permformed to determine the sensitivity coefficients which were used to study the parametric dependence of the biological models.
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== Structural Model ==
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Revision as of 09:08, 19 September 2012

Menu

Human Outreach

Human Outreach


Our aim in Human Outreach was to spread our word among a broad audience. We invested a lot of time and effort but we have been rewarded with many opportunities. Frank Theys is making a documentary about us and a few other laboratories. We were invited to discuss our project at the Life Symposium. We educated children at the Floriade and at the Nacht van de Kunst & Wetenschap. We discussed and explained our project at Llowlab, part of Lowlands, to (young) adults with many different backgrounds. So these past few months many interesting, critical and curious people crossed our path and we have been delighted to educate them and discuss our project with them.

Click on the photo to see a more detailed project description

Floriade
Documentary
Nacht van de Kunst en Wetenschap
Life Symposium
Lowlands - Llowlab

Retrieved from "http://2012.igem.org/Team:TU-Delft/Modeling"