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Team:TU-Delft
From 2012.igem.org
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| - | < | + | <strong style="font-size:120%;">The Challenge</strong><br/> |
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| + | <p>Biological drugs such as hormones, enzymes, cytokines or antibodies are increasingly used to treat different diseases. Due to systemic administration, these drugs often have adverse effects. Additionally, the high cost of biopharmaceuticals imposes a heavy burden on health systems.</p> | ||
| + | <p>We aimed to use the principles of synthetic biology to develop an advanced and safe method of <i>in situ</i> production of biological drugs to increase the quality of patients' lives. This system should increase compliance to therapy, decreas the number of required invasive drug administrations and enable advanced multistage therapy while local administration could reduce the side effects. </p> | ||
| + | <p>We addressed this challenge by implementing microencapsulated engineered mammalian cells that can be regulated from the outside to produce different therapeutics. This system should be effective, reliable, safe and potentially more cost-effective.</p> | ||
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<h2><i>Snifferomyces</i>: A Tuberculosis Screening Automaton</h2> | <h2><i>Snifferomyces</i>: A Tuberculosis Screening Automaton</h2> | ||
Revision as of 14:41, 25 October 2012
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The Challenge Biological drugs such as hormones, enzymes, cytokines or antibodies are increasingly used to treat different diseases. Due to systemic administration, these drugs often have adverse effects. Additionally, the high cost of biopharmaceuticals imposes a heavy burden on health systems. We aimed to use the principles of synthetic biology to develop an advanced and safe method of in situ production of biological drugs to increase the quality of patients' lives. This system should increase compliance to therapy, decreas the number of required invasive drug administrations and enable advanced multistage therapy while local administration could reduce the side effects. We addressed this challenge by implementing microencapsulated engineered mammalian cells that can be regulated from the outside to produce different therapeutics. This system should be effective, reliable, safe and potentially more cost-effective. |
Snifferomyces: A Tuberculosis Screening Automaton
The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!
- Localization of receptor NR1 using FLAG
- Activation of receptor NR1 by the ligand niacin
- Activation of the reporter by the native ligand alpha pheromone
- Providing a platform to swap receptors, promoters and terminators more easy
- Device design for yeast olfactory detector
- Deterministic and stochastic simulations and property analyses of pathway model
- Data fitting for deterministic pathway model
- Prediction of a ligand-binding niche within the human niacin receptor 1 with Molecular Dynamics simulations
- To find stake holders and create awareness among our project, we presented our project to a very large audience by participating in several events like Llowlab on Lowlands and the Floriade.
- Our main goal is to innovate a diagnostic tool for tuberculosis, one of the major health issues in the world
- We have provided the iGEM Paris 2012 team two Biobricks. Together with the Amsterdam team we were able to organize a crash course on the area of synthetic biology and we were honored to attend the LIFE-symposium with the Cambrigde 2010-team.
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