Team:TU-Delft

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<h2>Project Abstract</h2>
 
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<p>The aim of this year’s iGEM project will be the synthesis of <b>an olfactory device for the purpose of characterization of volatile compound</b>. Here, the aim is to introduce <a href="https://2012.igem.org/Team:TU-Delft/part1#A3">olfactory receptor gene fusions</a> into Saccharomyces cerevisiae and linking these receptors to a <a href="https://2012.igem.org/Team:TU-Delft/part2#A3">transcription response</a>. Aims:
 
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<li>The diagnostics of the presence of tuberculosis bacteria in the lungs by sensing chemical compound methyl nicotinate by S. cerevisiae. For diagnostics, the response to these molecules is light, generated by the Lux proteins (visible blue light) or <a href="https://2012.igem.org/Team:TU-Delft/part2">GFP (fluorescent green)</a>.</li>
 
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<li><a href="https://2012.igem.org/Team:TU-Delft/part1#A3">Introducing receptors</a> for sensing the presence of banana-smell (iso-amyl acetate). This is done to see whether communication between S. cerevisiae and E. coli is possible by this volatile intermediate.</li>
 
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<li>Supplying a toolkit which allows scientists to <a href="https://2012.igem.org/Team:TU-Delft/part1#A3">introduce olfactory receptors</a> in yeast with minimal effort. Further we want to characterize the receptor parts submitted by the <a href="https://2009.igem.org/Team:HKU-HKBU">2009 Hongkong university</a>.</li>
 
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<h5>Yes! We are at the <em>National News</em>!!! You can read the article from <b>NRC Handelsblad</b> <a href="https://static.igem.org/mediawiki/igem.org/c/c7/ZomerrepoNRC7aug.pdf">here</a>! <br/>
 
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But this is not enough. We really need your enhancement in order to succeed to our effort. Please help us improve our world! You can find more information in our <b><a href="https://2012.igem.org/Team:TU-Delft/crowdfunding">Crowdfunding Page</a></b></h5>
 
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<h5> Do not forget to get our app at your phone!! Stay informed about all the updates in our wiki through your android !! To download it press <a href="https://play.google.com/store/apps/details?id=com.vansteinengroentjes.apps.igem" target="_blank">here</a> </h5><br/>
<h5> Do not forget to get our app at your phone!! Stay informed about all the updates in our wiki through your android !! To download it press <a href="https://play.google.com/store/apps/details?id=com.vansteinengroentjes.apps.igem" target="_blank">here</a> </h5><br/>
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<h6>You can also find us on <a href="https://www.facebook.com/TudelftIgem2012">facebook</a>! </h6>
 
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Revision as of 06:36, 26 October 2012

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Snifferomyces:Yeast with a sense of smell

G-protein–coupled receptors (GPCRs) form a remarkable modular system that allows transmission of a wide variety of signals over the cell membrane, between cells and over long distances in the human body. The GPCRs mediate a flow of information that tells the inside of cells about the conditions on their outside, which includes signals from neurotransmitters (such as adrenaline and dopamine), hormones (such as follicle stimulating hormone, which helps control ovulation), and even light in our eyes and smell molecules in our noses, thus acting as both the gatekeepers and molecular messengers of the cell.

There are around 800 known human GPCRs, of which about half are the olfactory receptors that allow us to distinguish thousands of different aromas. This basic molecular mechanism of olfactory receptor activation is conserved evolutionarily from yeast to humans.Drawing inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis, as part of this year’s iGEM competition we are aiming to use this molecular mechanism to develop a universal olfactory system for the purpose of characterization of volatile compounds, by introducing olfactory receptor gene fusions into Saccharomyces cerevisiae and linking these receptors to a transcription response.


Advanced to the World Championship Jamboree!!


Snifferomyces: A Tuberculosis Screening Automaton


The 2012 project of the TU Delft iGEM team, draws inspiration from the sniffer rats which can be trained to sniff out unexploded landmines and tuberculosis. Tuberculosis infects around 8 million people a year and kills approximately 2 million. Drugs to treat tuberculosis have been around for a long time, so a rapid diagnosis system can help curb the spread of the disease. This year our team takes the first steps to make for this problem a screening olfactory automation!






Do not forget to get our app at your phone!! Stay informed about all the updates in our wiki through your android !! To download it press here


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