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Modeling - mutual repressor switch

  1. Deterministic model
  2. Stochastic model
  3. C#Sim model

Stochastic model of the mutual repressor switch

Stochastic simulation revealed that the mutual repressor switch exhibited bistability only as long as there was no leaky expression present. Otherwise, cooperativity higher than 1 was required. Higher cooperativity improved leaky expression tolerance, but only to a certain threshold. Higher leaky expression resulted in lower stable-state levels.

Bistable behavior of the switch became inconsistent when a delay between transcription and translation was taken into account.

The model

The basis for the stochastic simulation of the mutual repressor switch was the following set of reactions that describe the dynamics of the switch:

Simulation results

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