Team:ETH Zurich/HumanPractice/NRP59

From 2012.igem.org

(Difference between revisions)
Line 5: Line 5:
=== Introduction ===  
=== Introduction ===  
-
In 2005, the Swiss decided on a five year Moratorium on the commercial use of GMPs in a referendum with 55.7 % in favor of the moratorium. At the same time, the government conducted a national research program (NRP) [[http://www.nfp59.ch]] with the title ‘Benefits and risks of the deliberate release of genetically modified plants’. The aim of NRP 59 was to do research on safety, benefits and risks of GMP regarding specifically the situation and conditions in Switzerland. <br \>
+
In 2005, the Swiss decided on a five year Moratorium on the commercial use of GMPs in a referendum with 55.7 % in favor of the moratorium. At the same time, the government conducted a national research program ([http://www.nfp59.ch NRP]) with the title ‘Benefits and risks of the deliberate release of genetically modified plants’. The aim of NRP 59 was to do research on safety, benefits and risks of GMP regarding specifically the situation and conditions in Switzerland. <br \>
In 2010, the moratorium was elongated for three more years until November 2013 to wait for the final results of NRP 59 and to make room for a broad public discussion of the topic. <br \>
In 2010, the moratorium was elongated for three more years until November 2013 to wait for the final results of NRP 59 and to make room for a broad public discussion of the topic. <br \>
-
This year, 2012, the NFP 59 published its results. We want to take the opportunity to let people from other countries know how Switzerland deals with genetically modified plants (GMP). To further access the results of NFP 59 critically, we talked to two important players that have an impact on Swiss plant biotechnology: Mr. Markus Ritter, member of the Swiss National Council and head of the swiss farmers’ association ([[http://markusritter.ch/]], in German, French or Italian) and Prof. Ingo Potrykus [[http://en.wikipedia.org/wiki/Ingo_Potrykus]], who is one of the inventors of ‘golden rice’ [[http://www.goldenrice.org/]]. Both were so kind to answer a few of our questions which answers are included in this essay. Read the English translation as well as the German original of the full interview with Prof. Potrykus and Mr. Markus Ritter. <br \>
+
This year, 2012, the NFP 59 published its results. We want to take the opportunity to let people from other countries know how Switzerland deals with genetically modified plants (GMP). To further access the results of NFP 59 critically, we talked to two important players that have an impact on Swiss plant biotechnology: [http://markusritter.ch/ Mr. Markus Ritter], member of the Swiss National Council and head of the swiss farmers’ association, in German, French or Italian) and[http://en.wikipedia.org/wiki/Ingo_Potrykus Prof. Ingo Potrykus], who is one of the inventors of ‘[http://www.goldenrice.org/ golden rice]'. Both were so kind to answer a few of our questions which answers are included in this essay. Read the English translation as well as the German original of the full interview with Prof. Potrykus and Mr. Markus Ritter. <br \>

Revision as of 10:25, 25 September 2012

Eth ecolipseeth logo.png
Eth igem logo.png

Contents

NRP 59

Introduction

In 2005, the Swiss decided on a five year Moratorium on the commercial use of GMPs in a referendum with 55.7 % in favor of the moratorium. At the same time, the government conducted a national research program ([http://www.nfp59.ch NRP]) with the title ‘Benefits and risks of the deliberate release of genetically modified plants’. The aim of NRP 59 was to do research on safety, benefits and risks of GMP regarding specifically the situation and conditions in Switzerland.
In 2010, the moratorium was elongated for three more years until November 2013 to wait for the final results of NRP 59 and to make room for a broad public discussion of the topic.
This year, 2012, the NFP 59 published its results. We want to take the opportunity to let people from other countries know how Switzerland deals with genetically modified plants (GMP). To further access the results of NFP 59 critically, we talked to two important players that have an impact on Swiss plant biotechnology: [http://markusritter.ch/ Mr. Markus Ritter], member of the Swiss National Council and head of the swiss farmers’ association, in German, French or Italian) and[http://en.wikipedia.org/wiki/Ingo_Potrykus Prof. Ingo Potrykus], who is one of the inventors of ‘[http://www.goldenrice.org/ golden rice]'. Both were so kind to answer a few of our questions which answers are included in this essay. Read the English translation as well as the German original of the full interview with Prof. Potrykus and Mr. Markus Ritter.


Read the Interviews in full length

Interview with Prof. Ingo Potrykus in German original and English translation.
Interview with National Council Mr. Markus Ritter in German original and English translation.




References

  • Brown, B. a, Headland, L. R., & Jenkins, G. I. (2009). UV-B action spectrum for UVR8-mediated HY5 transcript accumulation in Arabidopsis. Photochemistry and photobiology, 85(5), 1147–55.
  • Christie, J. M., Salomon, M., Nozue, K., Wada, M., & Briggs, W. R. (1999): LOV (light, oxygen, or voltage) domains of the blue-light photoreceptor phototropin (nph1): binding sites for the chromophore flavin mononucleotide. Proceedings of the National Academy of Sciences of the United States of America, 96(15), 8779–83.
  • Christie, J. M., Arvai, A. S., Baxter, K. J., Heilmann, M., Pratt, A. J., O’Hara, A., Kelly, S. M., et al. (2012). Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. Science (New York, N.Y.), 335(6075), 1492–6.
  • Cloix, C., & Jenkins, G. I. (2008). Interaction of the Arabidopsis UV-B-specific signaling component UVR8 with chromatin. Molecular plant, 1(1), 118–28.
  • Cox, R. S., Surette, M. G., & Elowitz, M. B. (2007). Programming gene expression with combinatorial promoters. Molecular systems biology, 3(145), 145. doi:10.1038/msb4100187
  • Drepper, T., Eggert, T., Circolone, F., Heck, A., Krauss, U., Guterl, J.-K., Wendorff, M., et al. (2007). Reporter proteins for in vivo fluorescence without oxygen. Nature biotechnology, 25(4), 443–5
  • Drepper, T., Krauss, U., & Berstenhorst, S. M. zu. (2011). Lights on and action! Controlling microbial gene expression by light. Applied microbiology, 23–40.
  • EuropeanCommission (2006). SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion on Biological effects of ultraviolet radiation relevant to health with particular reference to sunbeds for cosmetic purposes.
  • Elvidge, C. D., Keith, D. M., Tuttle, B. T., & Baugh, K. E. (2010). Spectral identification of lighting type and character. Sensors (Basel, Switzerland), 10(4), 3961–88.
  • GarciaOjalvo, J., Elowitz, M. B., & Strogatz, S. H. (2004). Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing. Proceedings of the National Academy of Sciences of the United States of America, 101(30), 10955–60.
  • Gao Q, Garcia-Pichel F. (2011). Microbial ultraviolet sunscreens. Nat Rev Microbiol. 9(11):791-802.
  • Goosen N, Moolenaar GF. (2008) Repair of UV damage in bacteria. DNA Repair (Amst).7(3):353-79.
  • Heijde, M., & Ulm, R. (2012). UV-B photoreceptor-mediated signalling in plants. Trends in plant science, 17(4), 230–7.
  • Hirose, Y., Narikawa, R., Katayama, M., & Ikeuchi, M. (2010). Cyanobacteriochrome CcaS regulates phycoerythrin accumulation in Nostoc punctiforme, a group II chromatic adapter. Proceedings of the National Academy of Sciences of the United States of America, 107(19), 8854–9.
  • Hirose, Y., Shimada, T., Narikawa, R., Katayama, M., & Ikeuchi, M. (2008). Cyanobacteriochrome CcaS is the green light receptor that induces the expression of phycobilisome linker protein. Proceedings of the National Academy of Sciences of the United States of America, 105(28), 9528–33.
  • Kast, Asif-Ullah & Hilvert (1996) Tetrahedron Lett. 37, 2691 - 2694., Kast, Asif-Ullah, Jiang & Hilvert (1996) Proc. Natl. Acad. Sci. USA 93, 5043 - 5048
  • Kiefer, J., Ebel, N., Schlücker, E., & Leipertz, A. (2010). Characterization of Escherichia coli suspensions using UV/Vis/NIR absorption spectroscopy. Analytical Methods, 9660. doi:10.1039/b9ay00185a
  • Kinkhabwala, A., & Guet, C. C. (2008). Uncovering cis regulatory codes using synthetic promoter shuffling. PloS one, 3(4), e2030.
  • Krebs in Deutschland 2005/2006. Häufigkeiten und Trends. 7. Auflage, 2010, Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. (Hrsg). Berlin.
  • Lamparter, T., Michael, N., Mittmann, F., & Esteban, B. (2002). Phytochrome from Agrobacterium tumefaciens has unusual spectral properties and reveals an N-terminal chromophore attachment site. Proceedings of the National Academy of Sciences of the United States of America, 99(18), 11628–33.
  • Levskaya, A. et al (2005). Engineering Escherichia coli to see light. Nature, 438(7067), 442.
  • Mancinelli, A. (1986). Comparison of spectral properties of phytochromes from different preparations. Plant physiology, 82(4), 956–61.
  • Nakasone, Y., Ono, T., Ishii, A., Masuda, S., & Terazima, M. (2007). Transient dimerization and conformational change of a BLUF protein: YcgF. Journal of the American Chemical Society, 129(22), 7028–35.
  • Orth, P., & Schnappinger, D. (2000). Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nature structural biology, 215–219.
  • Parkin, D.M., et al., Global cancer statistics, 2002. CA: a cancer journal for clinicians, 2005. 55(2): p. 74-108.
  • Rajagopal, S., Key, J. M., Purcell, E. B., Boerema, D. J., & Moffat, K. (2004). Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. Photochemistry and photobiology, 80(3), 542–7.
  • Rizzini, L., Favory, J.-J., Cloix, C., Faggionato, D., O’Hara, A., Kaiserli, E., Baumeister, R., et al. (2011). Perception of UV-B by the Arabidopsis UVR8 protein. Science (New York, N.Y.), 332(6025), 103–6.
  • Roux, B., & Walsh, C. T. (1992). p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. Biochemistry, 31(30), 6904–10.
  • Strickland, D. (2008). Light-activated DNA binding in a designed allosteric protein. Proceedings of the National Academy of Sciences of the United States of America, 105(31), 10709–10714.
  • Sinha RP, Häder DP. UV-induced DNA damage and repair: a review. Photochem Photobiol Sci. (2002). 1(4):225-36
  • Sambandan DR, Ratner D. (2011). Sunscreens: an overview and update. J Am Acad Dermatol. 2011 Apr;64(4):748-58.
  • Tabor, J. J., Levskaya, A., & Voigt, C. A. (2011). Multichromatic Control of Gene Expression in Escherichia coli. Journal of Molecular Biology, 405(2), 315–324.
  • Thibodeaux, G., & Cowmeadow, R. (2009). A tetracycline repressor-based mammalian two-hybrid system to detect protein–protein interactions in vivo. Analytical biochemistry, 386(1), 129–131.
  • Tschowri, N., & Busse, S. (2009). The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli. Genes & development, 522–534.
  • Tschowri, N., Lindenberg, S., & Hengge, R. (2012). Molecular function and potential evolution of the biofilm-modulating blue light-signalling pathway of Escherichia coli. Molecular microbiology.
  • Tyagi, A. (2009). Photodynamics of a flavin based blue-light regulated phosphodiesterase protein and its photoreceptor BLUF domain.
  • Vainio, H. & Bianchini, F. (2001). IARC Handbooks of Cancer Prevention: Volume 5: Sunscreens. Oxford University Press, USA
  • Quinlivan, Eoin P & Roje, Sanja & Basset, Gilles & Shachar-Hill, Yair & Gregory, Jesse F & Hanson, Andrew D. (2003). The folate precursor p-aminobenzoate is reversibly converted to its glucose ester in the plant cytosol. The Journal of biological chemistry, 278.
  • van Thor, J. J., Borucki, B., Crielaard, W., Otto, H., Lamparter, T., Hughes, J., Hellingwerf, K. J., et al. (2001). Light-induced proton release and proton uptake reactions in the cyanobacterial phytochrome Cph1. Biochemistry, 40(38), 11460–71.
  • Wegkamp A, van Oorschot W, de Vos WM, Smid EJ. (2007 )Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis. Appl Environ Microbiol. Apr;73(8):2673-81.
Retrieved from "http://2012.igem.org/Team:ETH_Zurich/HumanPractice/NRP59"