Team:HIT-Harbin
From 2012.igem.org
<head> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <title>无标题文档</title> </head> <body> Staphylococcus aureus infections are a major caus of morbidity and mortality in community and hospital settings. Consequently, the emergence of methicillin-resistant and, more recently, vancomysin-resistant strains of S.aureus represents an enormous threat to public health. Since bacterial sensors are attracting more and more biologists' attention owing to its detecting specifically, quickly and accurately, we plan to construct a E.coli consortium consisting of two different engineered populations, which comprises consortium biofilm formation, S.aureus detecting, killing and bacterial lysis devices, that will enable the E.coli consortium to detect and kill a pathogen S.aureus. Finally, we will construct an enhanced consortium biofilm. The consortium biofilm is composed of the two different engineered E.coli populations, which is able to sense and kill S.aureus, respectively. The enhanced consortium biofilm can promote intra- and inter-species signal transduction, and stay stably. The detecting and killing system is distributed in two different engineered E.coli. This will make functions compartmental, and reduce metabolism load. On the other hand, this will promote modularity in the level of bacteria </body> </html> |