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Team:UANL Mty-Mexico/Modeling
From 2012.igem.org
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<p><br><h3>Modules</h3><br></p> | <p><br><h3>Modules</h3><br></p> | ||
<p>Our model for the E. cologic system is divided in three main modules:</p> | <p>Our model for the E. cologic system is divided in three main modules:</p> | ||
| - | <p><b>1.</b> Transport and accumulation</p> | + | <p><b><a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/transport_and_accumulation">1.</b> Transport and accumulation</a></p> |
| - | <p><b>2.</b> Biosensor</p> | + | <p><b><a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Biosensor">2.</b> Biosensor</a></p> |
| - | <p><b>3.</b> Silica binding</p> | + | <p><b><a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Silica_binding">3.</b> Silica binding</a></p> |
<p>Whenever possible, we will make a model in an unicellular, genetic circuit level (as is the case for the Biosensor module); but usually, we'll be modeling in a population level. </p> | <p>Whenever possible, we will make a model in an unicellular, genetic circuit level (as is the case for the Biosensor module); but usually, we'll be modeling in a population level. </p> | ||
<p>The goal of both models is to predict the change in the concentration of arsenic and the biosensor activity after exposure to the E. cologic system.</p> | <p>The goal of both models is to predict the change in the concentration of arsenic and the biosensor activity after exposure to the E. cologic system.</p> | ||
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<ul class="nav"> | <ul class="nav"> | ||
<a href="#"><li><b>>>Modeling</b></a></li> | <a href="#"><li><b>>>Modeling</b></a></li> | ||
| - | <a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/transport_and_accumulation"<li>Transport and accumulation</a></li> | + | <a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/transport_and_accumulation"><li>Transport and accumulation</a></li> |
<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Biosensor"><li>Biosensor</a></li> | <a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Biosensor"><li>Biosensor</a></li> | ||
<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Silica_binding"><li>Silica binding</a></li> | <a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/Silica_binding"><li>Silica binding</a></li> | ||
Revision as of 20:34, 21 September 2012
Modeling
Modules
Our model for the E. cologic system is divided in three main modules:
Whenever possible, we will make a model in an unicellular, genetic circuit level (as is the case for the Biosensor module); but usually, we'll be modeling in a population level.
The goal of both models is to predict the change in the concentration of arsenic and the biosensor activity after exposure to the E. cologic system.
General procedure
Our models consist on a series of ODEs, whose parameters have been obtained through a literature and previous work review or through experimental work by our team. However, there are some points where we do not have any suitable data; in these cases, we left only the enunciation of our model, along with a steady state analysis.
The ODEs and the equations for the steady state analysis were represented and solved using Simulink and the ODE solvers embedded.
