Team:Goettingen

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Visit our <a href="https://2012.igem.org/Team:Goettingen/Team">team site</a> to learn more about us and our supporters and advisors!
Visit our <a href="https://2012.igem.org/Team:Goettingen/Team">team site</a> to learn more about us and our supporters and advisors!
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And, last but not least, do not forget to check out our mascot  <a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">"Flash Coli"</a>! He always has some interesting stories to tell and needs YOUR help to fight the horrible phages!
And, last but not least, do not forget to check out our mascot  <a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">"Flash Coli"</a>! He always has some interesting stories to tell and needs YOUR help to fight the horrible phages!
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<img width="400 px" src="http://www.patrickreinke.de/igem/homingcoli.jpg"></td>
<img width="400 px" src="http://www.patrickreinke.de/igem/homingcoli.jpg"></td>
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<td valign="top"; cellpadding="30"><font size="-1">  <a href="http://jb.asm.org/content/186/22/7529.full"> <p align="justify">Clive S. Barker <i> et al. </i> (2004). Increased Motility of <i> Escherichia coli </i> by Insertion Sequence Element
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<td valign="top"; cellpadding="30"><font size="-2">  <a href="http://jb.asm.org/content/186/22/7529.full"> <p align="justify">Clive S. Barker <i> et al. </i> (2004). Increased Motility of <i> Escherichia coli </i> by Insertion Sequence Element
Integration into the Regulatory Region of the flhD Operon. Journal of Bacteriology, Vol. 186: 7529-7537.</a> </font><br>
Integration into the Regulatory Region of the flhD Operon. Journal of Bacteriology, Vol. 186: 7529-7537.</a> </font><br>
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<h2><b><a name="Synthetic_Biology"></a>Synthetic Biology</b></h2>
<h2><b><a name="Synthetic_Biology"></a>Synthetic Biology</b></h2>
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<img src="http://www.patrickreinke.de/igem/synbio.jpg">
<img src="http://www.patrickreinke.de/igem/synbio.jpg">
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<font size="-1">After Nandagopaland and Elowitz (2011). A continuum of synthetic biology. Wild-type cells (<b>A</b>) can be subject to two basic types of synthetic manipulation. (<b>B</b>) Autonomous synthetic circuits, consisting of ectopic components, may be introduced into the cell. Such circuits process inputs and implement functions (red arrows) seperate from the endogenous circuitry (black). However, unknown interactions with the host cell may affect their function (purple arrows) (<b>C</b>)An alternative is to rewire (red lines) the endogenous circuits themselves to have new connectivity. (<b>D</b>) Extending this line of synthetic manipulation, synthetic circuits could be integrated into appropriately rewired endogenous circuitry to act as sensors and to implent additional functionality. Ultimate goals of this program are to be able to design and construct (<b>E</b>) synthetic circuits that can functionality replace endogenous circuits or (<b>F</b>) fully autonomous circuits that operate independently of the cellular mileu.</font>
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<font size="-2">After Nandagopaland and Elowitz (2011). A continuum of synthetic biology. Wild-type cells (<b>A</b>)
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can be subject to two basic types of synthetic manipulation. (<b>B</b>) Autonomous synthetic circuits, consisting of
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ectopic components, may be introduced into the cell. Such circuits process inputs and implement functions (red arrows)
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        <font size="-1">  <a href="http://www.its.caltech.edu/~haylab/research/SBReview2011.pdf">Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated
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seperate from the endogenous circuitry (black). However, unknown interactions with the host cell may affect their function
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(purple arrows) (<b>C</b>)An alternative is to rewire (red lines) the endogenous circuits themselves to have new connectivity.
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(<b>D</b>) Extending this line of synthetic manipulation, synthetic circuits could be integrated into appropriately rewired
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endogenous circuitry to act as sensors and to implent additional functionality. Ultimate goals of this program are to be
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able to design and construct (<b>E</b>) synthetic circuits that can functionality replace endogenous circuits or (<b>F</b>)
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fully autonomous circuits that operate independently of the cellular mileu.
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<a href="http://www.its.caltech.edu/~haylab/research/SBReview2011.pdf">Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated
Gene Circuits. SCIENCE, Vol. 333: 1244-1248.</a> </font><br>
Gene Circuits. SCIENCE, Vol. 333: 1244-1248.</a> </font><br>
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Another very important and necessary feature of biological parts is orthogonality,
Another very important and necessary feature of biological parts is orthogonality,
which means in this context that independent devices can be combined unrestrictedly.
which means in this context that independent devices can be combined unrestrictedly.

Revision as of 12:19, 17 September 2012



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