Team:Arizona State/Problem

From 2012.igem.org

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...how can you have a project without a problem? <font color=blue>Dr. Haynes: the problem is detecting invisible signal in a water sample. You have to detect and amplify in a way that is cost effective and easy to use, right?</font>
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Viewed as a minor inconvenience in the developed world, diarrhea can be a death sentence in developing countries. Diarrhea can be life threatening as it causes severe dehydration as a result of extensive fluid loss. An estimated 2.0 billion cases of diarrhea occur each year amongst children under five years of age. Of these cases, 1.5 million children die.  The major pathogens that most frequently cause acute childhood diarrhea cases are bacterial pathogens such as E. coli, Shigella, Campylobacter and Salmonella. The ASU iGEM team plans to develop an inexpensive way for communities to test the purity of water sources- and identify the specific pathogens in the water source- in efforts of reducing the incidence of childhood diarrhea and ultimately decreasing mortality rates. </font>
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...be more detailed than Abstract/Overview
 
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...to Abhi: what is the difference between Abstract and Overview?
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Revision as of 01:43, 4 October 2012

Detailed Problem Description

What is the problem we want to solve

Viewed as a minor inconvenience in the developed world, diarrhea can be a death sentence in developing countries. Diarrhea can be life threatening as it causes severe dehydration as a result of extensive fluid loss. An estimated 2.0 billion cases of diarrhea occur each year amongst children under five years of age. Of these cases, 1.5 million children die. The major pathogens that most frequently cause acute childhood diarrhea cases are bacterial pathogens such as E. coli, Shigella, Campylobacter and Salmonella. The ASU iGEM team plans to develop an inexpensive way for communities to test the purity of water sources- and identify the specific pathogens in the water source- in efforts of reducing the incidence of childhood diarrhea and ultimately decreasing mortality rates.


Quantitative considerations

...What concentration of pathogens causes sickness?
...What specific design approaches did we take to try to reduce false positives, while making the biosensor effective?


Why are we doing this?

...what do we hope to accomplish/want to figure out?
...who are we doing this for? what do we care about? tie in to human practices and provide links
...what is our ultimate goal?


How we are doing it

...what are our methods?
...How is this different compared what others have done?
...what has already been tried?


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