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Team:HKUST-Hong Kong/Design Module
From 2012.igem.org
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<h1><p align=center>Target Binding Module</p></h1> | <h1><p align=center>Target Binding Module</p></h1> | ||
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| - | <p>Our decision to pursue colorectal carcinoma suppression arose from two key points obtained from preliminary research: 1) bone morphogenetic protein 2 ( | + | <p>Our decision to pursue colorectal carcinoma suppression arose from two key points obtained from preliminary research: 1) bone morphogenetic protein 2 (BMP2) suppresses the growth of colon cancer cell growth <i>in vivo</i>, and 2) the phage display peptide RPMrel confers specific and preferential binding to non-differentiated colon cancer cells......<a href="https://2012.igem.org/Team:HKUST-Hong_Kong/Module/Target_binding">Click to see more</a></p> |
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<div id="paragraph2" class="bodyParagraphs"> | <div id="paragraph2" class="bodyParagraphs"> | ||
Revision as of 13:49, 26 September 2012
Design - Module
Target Binding Module
Our decision to pursue colorectal carcinoma suppression arose from two key points obtained from preliminary research: 1) bone morphogenetic protein 2 (BMP2) suppresses the growth of colon cancer cell growth in vivo, and 2) the phage display peptide RPMrel confers specific and preferential binding to non-differentiated colon cancer cells......Click to see more
Anti-tumor Molecule Secretion Module
As our team objective is to provide a specific and efficient drug for Colon cancer, the way of drug synthesis and releasing is a significant part of our whole project. Hence this module is focusing on the production and delivery of anti-tumor drug......click to see more
Regulation and Control Module
Our module aims at regulating the growth of our engineered bacteria B. hercules and the production of the anti-tumor drug, BMP2. We first introduce a xylose inducible promoter, which can help us control the timing of BMP-2 expression and secretion. Our choice of xylose as an inducer stems from its induction efficiency, its little existence and low absorption rate in colon......click here to see more
