Team:GoettingenNeu

From 2012.igem.org

(Difference between revisions)
(Replaced content with "{{GoettingenHeaderTest|deu=Team:GoettingenNeu|eng=Team:Goettingen}} {| style="width: 900px; margin:0 0 0 0; background:none; border-spacing: 0px" | style="padding: 0pt 20px ...")
Line 3: Line 3:
{| style="width: 900px; margin:0 0 0 0; background:none; border-spacing: 0px"
{| style="width: 900px; margin:0 0 0 0; background:none; border-spacing: 0px"
| style="padding: 0pt 20px 0pt 0pt;" width="630px" |
| style="padding: 0pt 20px 0pt 0pt;" width="630px" |
-
 
+
Spalte 1
-
== Welcome to iGEM Göttingen ==
+
-
 
+
-
In November 2011, most of us heard about iGEM competition for the first time.
+
-
Erik, inspired by his former colleagues's enthusiastic reports, was looking for like-minded people at his new university that
+
-
were willing to organize a whole project in the field of Synthetic Biology. He described the idea of the contest to anybody willing to listen. It did not take
+
-
long to find five other interested students. Thus, the so called organization task force of the first iGEM team of the University of Göttingen was formed.
+
-
 
+
-
Luckily, the iGEM competition was already well known among the University´s professors and the team found his first supporters: Prof. Heinz
+
-
Neumann, head of a work group specializing in Synthetic Biology, and Prof. Jörg Stülke from the department of General and Applied Microbiology.
+
-
The next task was to find a project that was interesting as well as realizable. After a lot of back and forth due to extensive discussions, Prof.
+
-
Neumann presented the perfect project: "Homing Coli"!
+
-
 
+
-
After many drawbacks, like finding a suitable laboratory to realize the project, the search for additional team members began. The new
+
-
fellows were quickly found, which was the story starting point of the first iGEM team of the University of Göttingen… Below you can see our timeline.<br><br>
+
-
 
+
-
[[File:Timeline.png|500px|thumb|The timeline of the iGEM team Göttingen 2012. Click on the picture for full size.]]
+
-
 
+
-
If you are interested in the <a href="https://2012.igem.org/Team:Goettingen/iGEM">iGEM competition</a>, the BioBrick concept, and – most importantly – <a href="https://2012.igem.org/Team:Goettingen/Project">our project</a>, take a look around. Here, you will find everything
+
-
you need to know about "Homing Coli" and you will have the opportunity to gather knowledge about chemotaxis in general!
+
-
<br>
+
-
Visit our <a href="https://2012.igem.org/Team:Goettingen/Team">team site</a> to learn more about us and our supporters and advisors!
+
-
And, last but not least, do not forget to check out our mascot  <a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">"Flash Coli"</a>! He always has some interesting stories to tell and needs YOUR help to fight the horrible phages!
+
-
<br><br>
+
-
Feel free to browse this page!<br><br>
+
-
</p>
+
-
<br>
+
-
 
+
-
== Homing Coli ==
+
-
 
+
-
<i>Escherichia coli</i> is a commonly used bacterial model organism. It has lots of beneficial
+
-
traits, e.g. a short generation time and it can be easily manipulated. Most <i>E. coli</i>
+
-
strains that are used in laboratories do not exhibit high motility. The crucial element for
+
-
motility is the flagellum, which is rotated by a molecular motor within the cell wall.
+
-
Consequently, these are reduced in cultivated <i>E. coli</i> strains.<br>
+
-
<br>
+
-
Our goal is to create an <i>E. coli</i> strain with increased swimming motility on special
+
-
agar plates. Therefore, we will overexpress regulators and parts of the <i>E. coli</i> flagellum in cultivated strains in order to enhance bacterial swimming ability. The fastest <i>E. coli</i> strains will be selected and
+
-
further improved. At the same time we will then be able to create an effective motility-selection
+
-
  method.        <br>
+
-
<br>
+
-
Now, you are probably wondering what the advantage of a fast <i> E. coli</i> might be. The
+
-
beneficial fast phenotype can be combined with the ability of this bacterium to sense
+
-
specific compounds in their environments. Chemoreceptors enable it to move towards
+
-
or along gradients of such substances. We will use PCR-based site directed mutagenesis on the <i> E. coli</i> Tar receptor. The combination of speed and chemotaxis allows
+
-
us to identify <i>E. coli</i> strains, which can sense interesting compounds. Thereby, an
+
-
easy method for the detection of pollutants, toxins or even tumors could be provided.<br><br>
+
-
 
+
-
http://www.patrickreinke.de/igem/homingcoli.jpg
+
-
 
+
-
[http://jb.asm.org/content/186/22/7529.full Clive S. Barker <i> et al. </i> (2004). Increased Motility of <i> Escherichia coli </i> by Insertion Sequence Element
+
-
Integration into the Regulatory Region of the flhD Operon. Journal of Bacteriology, Vol. 186: 7529-7537.]
+
-
 
+
-
== Synthetic Biology ==
+
-
 
+
-
Synthetic biology is an interdisciplinary scientific area that has recently developed.
+
-
It links various fields of science like biology, chemistry, physics, molecular genetics,
+
-
informatics and engineering.<br>
+
-
 
+
-
Due to this combination the relation of biological design and function can be investigated
+
-
from an entirely new perspective. The previous approach was limited to the examination of
+
-
a structure and its function and the attempt to explain how they correlate.
+
-
Recently, the reverse strategy is applied. Biological parts are specifically designed and
+
-
constructed according to a desired function. These parts are characterized by a standardized
+
-
modular design that facilitates their handling. The subsequent introduction of the synthetic
+
-
constructs to living cells can either cause the replacement of original cellular components
+
-
or result in additional elements that act cooperatively or more or less autonomously (see fig. 1).<br>
+
-
<br>
+
-
 
+
-
http://www.patrickreinke.de/igem/synbio.jpg
+
-
 
+
-
<font size="-2">After Nandagopaland and Elowitz (2011). A continuum of synthetic biology. Wild-type cells (<b>A</b>)
+
-
can be subject to two basic types of synthetic manipulation. (<b>B</b>) Autonomous synthetic circuits, consisting of
+
-
ectopic components, may be introduced into the cell. Such circuits process inputs and implement functions (red arrows)
+
-
seperate from the endogenous circuitry (black). However, unknown interactions with the host cell may affect their function
+
-
(purple arrows) (<b>C</b>)An alternative is to rewire (red lines) the endogenous circuits themselves to have new connectivity.
+
-
(<b>D</b>) Extending this line of synthetic manipulation, synthetic circuits could be integrated into appropriately rewired
+
-
endogenous circuitry to act as sensors and to implent additional functionality. Ultimate goals of this program are to be
+
-
able to design and construct (<b>E</b>) synthetic circuits that can functionality replace endogenous circuits or (<b>F</b>)
+
-
fully autonomous circuits that operate independently of the cellular mileu.
+
-
 
+
-
<a href="http://www.its.caltech.edu/~haylab/research/SBReview2011.pdf">Nagarajan Nandagopal and Michael B. Elowitz. (2011). Synthetic Biology: Integrated
+
-
Gene Circuits. SCIENCE, Vol. 333: 1244-1248.</a> </font><br>
+
-
<br>
+
-
 
+
-
<font size="-1">
+
-
Another very important and necessary feature of biological parts is orthogonality,
+
-
which means in this context that independent devices can be combined unrestrictedly.
+
-
  This principle derives from the area of engineering and aims to alter subsystems,
+
-
  without impeding others.<br>
+
-
<br>
+
-
This way cells can be modified as requested, resulting in a predictable behaviour.
+
-
Among others, this technique can be beneficial for the effective production of
+
-
certain substances, like biofuels or antibiotics.
+
-
 
+
-
<br>
+
-
<br>
+
-
 
+
-
<!-- START - Do not touch this table! -->
+
-
<html>
+
-
<table bordercolor="black" border="1 px" width="600 px"><tr><td>
+
-
<b>Important pages</b>:<br>
+
-
<a href="https://2012.igem.org/Team:Goettingen">Home</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Team">Team</a>;
+
-
<a href="https://igem.org/Team.cgi?year=2012">Official Team Profile</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Project">Project</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Parts">Parts submitted to the Registry</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Modeling">Modeling</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Notebook">Notebook</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Saftey">Saftey</a>;
+
-
<a href="https://2012.igem.org/Team:Goettingen/Attributions">Attributions</a>
+
-
</td></tr>
+
-
</table>
+
-
</html>
+
-
<!-- END - Do not touch this table! -->
+
-
 
+
| style="width:240px" |
| style="width:240px" |
-
 
+
Spalte 2
-
<html>
+
-
 
+
-
<h2><hr><span><b>Flash Coli</b></span></h2>
+
-
<!-- News cap end -->
+
-
<embed src="http://www.patrickreinke.de/igem/motionflashcoli.swf" type="application/x-shockwave-flash"
+
-
pluginspage="http://www.macromedia.com/go/getflashplayer" wmode="transparent" height="180" width="240">
+
-
<font face="Verdana" size="-1">To explore our project with Flash Coli click
+
-
<a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">here</a>.
+
-
</font></p>
+
-
<br>
+
-
<p>
+
-
</p><p>
+
-
<font face="Verdana" size="-1">
+
-
 
+
-
</p>
+
-
<!-- News cap -->
+
-
<h2><hr><span><b>News</b></span></h2>
+
-
<!-- News cap end -->
+
-
 
+
-
<font align="left">
+
-
<br>
+
-
          <!-- News 17 -->
+
-
<p align="left"><i>07 September 2012,</i>  <b>We organized the "Legoland for Scientists" symposium at the University of Göttingen.
+
-
You can read everything about it <a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Panel_Discussion">here.</a></b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#17">To the news</a><br>
+
-
        <!-- News 17 end--><br><hr>
+
-
 
+
-
          <!-- News 16 -->
+
-
<p align="left"><i>30 August 2012,</i>  <b>The first version of "Flash Coli - the game" is now online. Click
+
-
<a href="https://2012.igem.org/Team:Goettingen/Human_Practice/Flash_coli">here.</a></b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#15">To the news</a><br>
+
-
        <!-- News 16 end--><br><hr>
+
-
 
+
-
          <!-- News 15 -->
+
-
<p align="left"><i>25 August 2012,</i>  <b>Today is the "Synthetic Biology" day in Germany!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#15">To the news</a><br>
+
-
        <!-- News 15 end--><br><hr>
+
-
 
+
-
          <!-- News 14 -->
+
-
<p align="left"><i>15 August 2012,</i>  <b>In our weekly seminar Anna presented an example for Synthetic Biology.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#14">To the news</a><br>
+
-
        <!-- News 14 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 13 -->
+
-
<p align="left"><i>08 August 2012,</i>  <b> Survey: Ready to be asked? </b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#13">To the news</a><br>
+
-
        <!-- News 13 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 12.75 -->
+
-
<p align="left"><i>01 August 2012,</i>  <b>Ali and Sandra conducted their presentations in our weekly seminar.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#12.75">To the news</a><br>
+
-
        <!-- News 12.75 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 12.5 -->
+
-
<p align="left"><i>19 August 2012,</i>  <b>Human practice task force established!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#12.5">To the news</a><br>
+
-
        <!-- News 12.5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 12 -->
+
-
<p align="left"><i>12 July 2012,</i>  <b>In today’s weekly meeting Christian told us about the European teacher meet-up in Paris.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#12">To the news</a><br>
+
-
        <!-- News 12 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
      <!-- News 11.5 -->
+
-
<p align="left"><i>04 July 2012,</i>  <b>Let there be light!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#11.5">To the news</a><br>
+
-
        <!-- News 11.5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 11 -->
+
-
<p align="left"><i>28 June 2012,</i>  <b>Anna, Corinna and Erik participated in the third annual congress for strategy processes "Biotechnology 2020+".</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#11">To the news</a><br>
+
-
        <!-- News 11 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
      <!-- News 10.5 -->
+
-
<p align="left"><i>26 June 2012,</i>  <b><i>E. coli</i> strain spurred!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#10.5">To the news</a><br>
+
-
        <!-- News 10.5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 10 -->
+
-
<p align="left"><i>21 June 2012,</i>  <b>Our first poster is designed!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#10">To the news</a><br>
+
-
        <!-- News 10 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 9.5 -->
+
-
<p align="left"><i>13 June 2012,</i>  <b>Task: Find a human practice project!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#9.5">To the news</a><br>
+
-
        <!-- News 9.5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 9 -->
+
-
<p align="left"><i>06 June 2012,</i>  <b>Thomas Maschner, advisor from the iGEM team of the LMU Munich, came to visit us.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#9">To the news</a><br>
+
-
        <!-- News 9 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 8.5 -->
+
-
<p align="left"><i>01 June 2012,</i>  <b>Discussion of the first lab results</b> 
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#8.5">To the news</a><br>
+
-
        <!-- News 8.5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 8 -->
+
-
<p align="left"><i>15 May 2012,</i>  <b>The first picture of our complete team.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#8">To the news</a><br>
+
-
        <!-- News 8 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
          <!-- News 7 -->
+
-
<p align="left"><i>11 May 2012,</i>  <b>iGEM Göttingen is in the local newspaper.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#7">To the news</a><br>
+
-
        <!-- News 7 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 6 --> <br>
+
-
<p align="left"><i>04 May 2012,</i>  <b><a href="http://www.kws.com/">KWS SAAT AG</a> is now Head Sponsor.</b>
+
-
</p>
+
-
<p align="left">
+
-
<center><img width="150 px" src="http://www.patrickreinke.de/igem/kws.png"></center>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#6">To the news</a><br>
+
-
        <!-- News 6 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 5 -->
+
-
<p align="left"><i>02 May 2012,</i>  <b>Today Anna presented our iGEM logo.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#5">To the news</a><br>
+
-
        <!-- News 5 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 4 -->
+
-
<p align="left"><i>30 April 2012,</i>  <b>We inspect the laboratory at the Max Planck campus.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#4">To the news</a><br>
+
-
        <!-- News 4 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 3 -->
+
-
<p align="left"><i>26 April 2012,</i>  <b>Weekly meeting: PCR-Lecture from Heinz.</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#3">To the news</a><br>
+
-
        <!-- News 3 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 2 -->
+
-
<p align="left"><i>19 April 2012,</i>  <b>The iGEM team Göttingen 2012 is now complete!</b>
+
-
</p>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#2">To the news</a><br>
+
-
        <!-- News 2 end--><br><hr>
+
-
 
+
-
 
+
-
 
+
-
        <!-- News 1 -->  <br>
+
-
<p><i>04 April 2012,</i>    <b> <a href="http://www.sartorius.com/">Sartorius Stedim Biotech GmbH</a> is now Premium Sponsor.</b>
+
-
</p>
+
-
<p>
+
-
<center><img width="240 px" src="http://www.patrickreinke.de/igem/sartorius.png"></center>
+
-
<a href="https://2012.igem.org/Team:Goettingen/News#1">To the news</a><br><br><hr>
+
-
        <!-- News 1 end-->
+
-
</font>
+
-
</html>
+
|}
|}
{{GoettingenFooter}}
{{GoettingenFooter}}

Revision as of 12:52, 21 September 2012

Select your Language / Wähle deine Sprache ->  

Spalte 1

Spalte 2

↑ Back to top!

Retrieved from "http://2012.igem.org/Team:GoettingenNeu"