Team:Arizona State

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Arizona State's 2012 iGEM project aims to develop a portable water-borne pathogen biosensor feasible for real-time field application. To achieve both specificity and portability, the team is constructing two biosensors, each capable of detecting a specific pathogenic marker in water-borne bacteria. The first system, a split-enzyme engineered fusion protein, selectively binds to pathogen membranes in water samples and induces a colorimetric response. The second system will detect specific DNA sequences in pathogenic bacteria and activate a similar colorimetric change. The advantage of this design over previous designs in the field lies in the cheap production of probes and the enzymatic chain reaction. Samples can be tested in the field with minimal cost and high sensitivity.
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    <td width="57"><img src="https://static.igem.org/mediawiki/2012/1/13/Raindrop.png" alt="" width="53" height="62" /></td>
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    <td width="415"><h4>The Problem:<br />
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      Childhood Diarrhea From Contaminated Water</h4></td>
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    <td colspan="2"><a class="linkopacity" href="https://2012.igem.org/Team:Arizona_State/Problem"><img src="https://static.igem.org/mediawiki/2012/0/03/Asuigem_diseasemap.png" alt="" width="450" /></td>
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    <td colspan="2"><medium>Viewed as a minor inconvenience in the developed world, diarrhea can be a death sentence in developing countries. Diarrhea can be life threatening as it causes severe dehydration as a result of extensive fluid loss. An estimated 2.0 billion cases of diarrhea occur each year amongst children under five years of age. Of these cases, 1.5 million children die. The major bacterial pathogens that most frequently cause acute childhood diarrhea are  <i>E. coli, Shigella, Campylobacter</i> and <i>Salmonella</i>. Currently, existing biosensors for water-borne pathogens are either costly, inaccessible to developing countries, require expensive equipment constrained to a lab setting, difficult to use without training, and not very reliable...<a href="https://2012.igem.org/Team:Arizona_State/Problem"><strong>More &gt;</strong></a></small></td>
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          <td width="155"><p align="center"><a class="linkopacity" href="https://2012.igem.org/Team:Arizona_State/Overview">
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          <td><p align="center"><a class="linkopacity" href="https://2012.igem.org/Team:Arizona_State/International">
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Latest revision as of 03:39, 27 October 2012



The Problem:
Childhood Diarrhea From Contaminated Water
Viewed as a minor inconvenience in the developed world, diarrhea can be a death sentence in developing countries. Diarrhea can be life threatening as it causes severe dehydration as a result of extensive fluid loss. An estimated 2.0 billion cases of diarrhea occur each year amongst children under five years of age. Of these cases, 1.5 million children die. The major bacterial pathogens that most frequently cause acute childhood diarrhea are E. coli, Shigella, Campylobacter and Salmonella. Currently, existing biosensors for water-borne pathogens are either costly, inaccessible to developing countries, require expensive equipment constrained to a lab setting, difficult to use without training, and not very reliable...More >

 

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