Team:UANL Mty-Mexico/Modeling main

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<p><br><h2>Modeling</h2><br></p>
 
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<p><br><h3>Modules</h3><br></p>
 
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<p>Our model for the E. cologic system is divided in three main modules:</p>
 
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<p><b>1.</b> Transport and accumulation</p>
 
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<p><b>2.</b> Biosensor</p>
 
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<p><b>3.</b> Silica binding</p>
 
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<p>Whenever possible, we will make a model in an unicellular, genetic circuit level (as is the case for the Biosensor module); but usually, we'll be modeling in a population level. </p>
 
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<p>The goal of both models is to predict the change in the concentration of arsenic and the biosensor activity after exposure to the E. cologic system.</p>
 
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<p><br><h3>General procedure</h3><br></p>
 
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<p>Our models consist on a series of ODEs, whose parameters have been obtained through a literature and previous work review or through experimental work by our team. However, there are some points where we do not have any suitable data; in these cases, we left only the enunciation of our model, along with a steady state analysis.</p>
 
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<p>The ODEs and the equations for the steady state analysis were represented and solved using Simulink and the ODE solvers embedded.</p>
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<br><p><h1>Modeling</h1></p></br>
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<p>Beside the experimental work we did for our project "E.cologic", we also developed some theoretical models.</p>
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<p>These models can be divided in two main categories:</p>
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<LI><a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling">Mathematical model</a> (a deterministic, ODE model).
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<LI><a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/3Dmodel">Protein structure model</a> (simulations for the prediction of the structure of the proteins involved in our system).
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<a href="#"><li><b>>>Modeling (main)</b></a></li>
<a href="#"><li><b>>>Modeling (main)</b></a></li>
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<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/modeling"><li>Mathematical model</a></li>
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<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling"><li>Mathematical model</a></li>
<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/3Dmodel"><li>Protein structure model</a></li>
<a href="https://2012.igem.org/Team:UANL_Mty-Mexico/Modeling/3Dmodel"><li>Protein structure model</a></li>

Latest revision as of 22:02, 22 September 2012

iGEM UANL 2012


Modeling


Beside the experimental work we did for our project "E.cologic", we also developed some theoretical models.

These models can be divided in two main categories:


  • Mathematical model (a deterministic, ODE model).
  • Protein structure model (simulations for the prediction of the structure of the proteins involved in our system).

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