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Team:Slovenia/ModelingMutualRepressorSwitchStochastic
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Revision as of 22:34, 25 September 2012
Modeling - mutual repressor switch
- Deterministic model
- Stochastic model
- C#Sim model
Stochastic model of the mutual repressor switch
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Stochastic simulation revealed that the mutual repressor switch exhibited bistability only as long as there was no leaky expression present. Otherwise, cooperativity higher than 1 was required. Higher cooperativity improved leaky expression tolerance, but only to a certain threshold. Higher leaky expression resulted in lower stable-state levels. Bistable behavior of the switch became inconsistent when a delay between transcription and translation was taken into account. |
The model
The basis for the stochastic simulation of the mutual repressor switch was the following set of reactions that describe the dynamics of the switch:
Simulation results
Next: C#Sim model of the mutual repressor switch >>
