A synergistic approach to biological computing
The goal of the 2012 University of Texas at Dallas IGEM team is to redefine biological information processing using quorum signaling-based biological circuitry in bacteria. Quorum signaling allows bacteria to communicate with each other through the use of chemical signals. Bacteria use this form of signaling in nature to coordinate their behavior. Using three quorum signaling molecules we create unique connections between different populations of engineered bacteria and perform coordinated computing functions. We design and characterize standard and novel modules such as toggle switches, oscillators, signal propagators, and logic gates. As compared to engineering molecular circuitry in single populations, we aim to show that the synergistic approach to information processing leads to improved, scalable, and tunable operation.
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