Team:TU Munich/Modeling/Gal1 Promoter
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=== Parameters === | === Parameters === | ||
+ | {|cellspacing="0" border="1" | ||
+ | |'''Name''' | ||
+ | |'''Description''' | ||
+ | |'''Prior?''' | ||
+ | |- | ||
+ | | μ | ||
+ | | Scaling factor | ||
+ | | NO | ||
+ | |- | ||
+ | | k<sub>i</sub> | ||
+ | | Induced transcription rate | ||
+ | | YES | ||
+ | |- | ||
+ | | α | ||
+ | | Leaky transcription rate | ||
+ | | NO | ||
+ | |- | ||
+ | | γ<sub>1</sub> | ||
+ | | mRNA degradation rate | ||
+ | | NO | ||
+ | |- | ||
+ | | k<sub>2</sub> | ||
+ | | Protein synthesis rate | ||
+ | | NO | ||
+ | |- | ||
+ | | &gamma<sub>2</sub> | ||
+ | | Protein degradation rate | ||
+ | | NO | ||
+ | |} | ||
=== Data === | === Data === |
Revision as of 14:52, 11 September 2012
Contents |
Gal1 Promoter
Model Specification
Model Equations
We used a two species approach for mRNA and Protein concentrations. x1 and x2 represent the mRNA and protein levels for the induced promoter and x3 and x4 the respective levels for the uninduced promoter.
As no analysis was done with several galactose concentrations hence the hill function that normally models the response to the concentration was replaced by a single factor to improve identifiability.
Parameters
Name | Description | Prior? |
μ | Scaling factor | NO |
ki | Induced transcription rate | YES |
α | Leaky transcription rate | NO |
γ1 | mRNA degradation rate | NO |
k2 | Protein synthesis rate | NO |
&gamma2 | Protein degradation rate | NO |
Data
Profile Likelihood
Markov Analysis
Joint Distribution
Credibility Intervals
Sensitivity Analysis