Team:St Andrews/Human-practices

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Revision as of 17:16, 28 June 2012

Scientific impact of iGEM

"The most influential Synthetic Biology competition" vs. "let the kids play"


Introduction

Team St Andrews forms, uniting nine students, seven world class researchers and four PhD advisors from disciplines as diverse as Computer Science and Physics, to Biology, Medicine and Chemistry.

January - March 2012

Applications for sponsorship are made to specifically chosen businesses and organisations with an interest in advancing the Life Sciences. Very quickly, "BioSilta", "GenScript", "Clontech", "Geneious", "Integrated DNA Technologies" and "Thermo Fisher" pledge their support and Team St Andrews grows...

10 March 2012

National Science and Engineering Week explodes in Fife with a regional "Science Discovery Day". Team St Andrews works to convey fundamental concepts in Genetic Engineering and Synthetic Biology to members of the public in new and exciting ways. The interactive "Codon Game", the 3 Dimensional visualisations of DNA and DNA polymerase 3 and display "E. Coli: under the Microscope" are all well received. Children and adults alike are fascinated when DNA is extracted from bananas, using everyday kitchen utensils, before their eyes.

April 2012

Brainstorming sessions are held as the team researches project ideas. Some promising titles include:

  • "E. Coli and Omega 3: A Project to Feed the Minds of Our Generation"

  • "Enzymatic Methane Conversion in Cows: a Sweet Smelling Approach to Reducing Climate Change"

  • "Resurfacing Science, Resurfacing our Roads: Cell Factories and Metal Binding Proteins Recover Pavement Platinum"

  • "Project Bio-logic-al: Optimizing Soil Composition by Method of Biological Computation"

27 April 2012

Team member Josi presents "Spider Mutants and Bioterrorism - an Overview of Synthetic Biology as an Emerging Scientific Discipline" to a “TEDx” audience of over eighty scientists and non - scientists akin. Josi views the field as "ground breaking" and by the end of her talk, members of her audience too admit surprise at the wealth of possibilities that this new research area makes available. There is excitement at the tantalizing proximity of reality of these ideas.

May 2012

Project ideas are discussed in greater detail and are filtered until only two research topics remain. Those preferred ideas are: the production of Omega 3 Fatty Acids by E. Coli Cells ("E. Coli and Omega 3: A Project to Feed the Minds of Our Generation") and the production of Metal – Binding Proteins ("Resurfacing Science, Resurfacing our Roads: Cell Factories and Metal Binding Proteins Recover Pavement Platinum").


Data collection

Anim pariatur cliche reprehenderit, enim eiusmod high life accusamus terry richardson ad squid. 3 wolf moon officia aute, non cupidatat skateboard dolor brunch. Food truck quinoa nesciunt laborum eiusmod. Brunch 3 wolf moon tempor, sunt aliqua put a bird on it squid single-origin coffee nulla assumenda shoreditch et. Nihil anim keffiyeh helvetica, craft beer labore wes anderson cred nesciunt sapiente ea proident. Ad vegan excepteur butcher vice lomo. Leggings occaecat craft beer farm-to-table, raw denim aesthetic synth nesciunt you probably haven't heard of them accusamus labore sustainable VHS.
Authors Title Year Source title Cited by Link
Boyle P.M.; Burrill D.R.; Inniss M.C.; Agapakis C.M.; Deardon A.; DeWerd J.G.; Gedeon M.A.; Quinn J.Y.; Paull M.L.; Raman A.M.; Theilmann M.R.; Wang L.; Winn J.C.; Medvedik O.; Schellenberg K.; Haynes K.A.; Viel A.; Brenner T.J.; Church G.M.; Shah J.V.; Silver P.A. A BioBrick compatible strategy for genetic modification of plants 2012 Journal of Biological Engineering http://www.scopus.com/inward/record.url?eid=2-s2.0-84862311887&amp;partnerID=40&amp;md5=c7d8f6c120046b10d7c2846035e8967a
Hesselman M.C.; Odoni D.I.; Ryback B.M.; de Groot S.; van Heck R.G.A.; Keijsers J.; Kolkman P.; Nieuwenhuijse D.; van Nuland Y.M.; Sebus E.; Spee R.; de Vries H.; Wapenaar M.T.; Ingham C.J.; Schroen K.; Martins dos Santos V.A.P.; Spaans S.K.; Hugenholtz F.; van Passel M.W.J. A multi-platform flow device for microbial (co-) cultivation and microscopic analysis 2012 PLoS ONE http://www.scopus.com/inward/record.url?eid=2-s2.0-84861008844&amp;partnerID=40&amp;md5=1d589179f1026c6b18561886eb95137f
Materi W. Leading a successful iGEM team 2012 Methods in Molecular Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-84858373911&amp;partnerID=40&amp;md5=c042ab8445472bde80fd097c2c7f5840
Ho-Shing O.; Lau K.H.; Vernon W.; Eckdahl T.T.; Campbell A.M. Assembly of standardized DNA parts using biobrick ends in E. coli 2012 Methods in Molecular Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-84858416895&amp;partnerID=40&amp;md5=257cf76e51c458476c1ba8c45ad53993
Giavitto J.-L. The modeling and the simulation of the fluid machines of synthetic biology 2012 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) http://www.scopus.com/inward/record.url?eid=2-s2.0-84856118515&amp;partnerID=40&amp;md5=b482e017a0312fc2b37771c0a2ebd016
Muller K.M.; Arndt K.M. Standardization in synthetic biology 2012 Methods in Molecular Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-82355181974&amp;partnerID=40&amp;md5=19e06cbf0e67855c668e52423d0eee2b
Kuldell N. Living machines: Some assembly required: Kit-based competitions challenge teams of students to learn microbiology and design principles in the context of synthetic biology 2012 Microbe http://www.scopus.com/inward/record.url?eid=2-s2.0-84855890383&amp;partnerID=40&amp;md5=704e642863324ba616224b7d2000c638
Stewart D.; Wilson-Kanamori J.R. Modular modelling in synthetic biology: Light-based communication in E. coli 2011 Electronic Notes in Theoretical Computer Science http://www.scopus.com/inward/record.url?eid=2-s2.0-80055072775&amp;partnerID=40&amp;md5=728eadae0407c4fb4d43d3c8d48648b9
Dixon J.; Kuldell N. BioBuilding: Using banana-scented bacteria to teach synthetic biology 2011 Methods in Enzymology 1 http://www.scopus.com/inward/record.url?eid=2-s2.0-79957526685&amp;partnerID=40&amp;md5=67f18898be70d64e4a5ca05e4f62b83b
Mitchell R.; Dori Y.J.; Kuldell N.H. Experiential Engineering Through iGEM-An Undergraduate Summer Competition in Synthetic Biology 2011 Journal of Science Education and Technology http://www.scopus.com/inward/record.url?eid=2-s2.0-79953037825&amp;partnerID=40&amp;md5=26f1a53f3e91cc6943854fc9a0b3bd02
Dress L. iGEM 2010: Synthetic biologists compete for the future 2010 Industrial Biotechnology http://www.scopus.com/inward/record.url?eid=2-s2.0-78650724541&amp;partnerID=40&amp;md5=c97c238e5d9425acfb58d30242e71484
Hafner S. IGEM 2009: Synthethic biology and ethics [Les iGEM 2009 la biologie synth-éthique] 2010 Medecine/Sciences 2 http://www.scopus.com/inward/record.url?eid=2-s2.0-78650166973&amp;partnerID=40&amp;md5=a6b997075a88a932c2dc7551f868bda7
Gu X.; Trybilo M.; Ramsay S.; Jensen M.; Fulton R.; Rosser S.; Gilbert D. Engineering a novel self-powering electrochemical biosensor 2010 Systems and Synthetic Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-77958488960&amp;partnerID=40&amp;md5=141f80bffe6c579c0029d9d7540fe9a0
Cai Y.; Wilson M.L.; Peccoud J. GenoCAD for iGEM: A grammatical approach to the design of standard-compliant constructs 2010 Nucleic Acids Research 12 http://www.scopus.com/inward/record.url?eid=2-s2.0-77952526654&amp;partnerID=40&amp;md5=ae3ab35cb311e0e1ddabb0cff9036f77
Cooling M.T.; Rouilly V.; Misirli G.; Lawson J.; Yu T.; Hallinan J.; Wipat A. Standard virtual biological parts: A repository of modular modeling components for synthetic biology 2010 Bioinformatics 10 http://www.scopus.com/inward/record.url?eid=2-s2.0-77951969603&amp;partnerID=40&amp;md5=6776faf8875e836fea00b273c28fa315
Smolke C.D. Building outside of the box: IGEM and the BioBricks Foundation 2009 Nature Biotechnology 15 http://www.scopus.com/inward/record.url?eid=2-s2.0-71849085372&amp;partnerID=40&amp;md5=ad462a440b094c7dc24c9ac9491546f1
Hafner S. iGEM competition 2008; two French teams! [Compétition iGEM 2008: Deux équipes françaises!] 2009 Medecine/Sciences 2 http://www.scopus.com/inward/record.url?eid=2-s2.0-66849142197&amp;partnerID=40&amp;md5=715e4423dfdd513949af6798ad32ea0c
Jerala R. I like iGEM 2009 Scientist http://www.scopus.com/inward/record.url?eid=2-s2.0-65349196705&amp;partnerID=40&amp;md5=cbfa881ac65c74d323c1bbf94cd47a0b
Edwards C. The gene machines 2008 Engineering and Technology http://www.scopus.com/inward/record.url?eid=2-s2.0-44449168043&amp;partnerID=40&amp;md5=6c08b9a9258980533bfca7f89c1a6d2f
Bikard D.; Kepes F. First French team success during iGEM Synthetic biology competition [Succès de la première équipe française lors de la compétition iGEM de biologie synthétique] 2008 Medecine/Sciences 6 http://www.scopus.com/inward/record.url?eid=2-s2.0-44949101352&amp;partnerID=40&amp;md5=b4b37b907403fc09040dc4d9dd01f9b8
Bachman R. An iGEM of an idea? [2] 2008 Scientist http://www.scopus.com/inward/record.url?eid=2-s2.0-39849096038&amp;partnerID=40&amp;md5=983ce8270f7b0b54a9a6dc9b35c61689
Kaczkowski P. An iGEM of an idea? [1] 2008 Scientist http://www.scopus.com/inward/record.url?eid=2-s2.0-39849093164&amp;partnerID=40&amp;md5=1af981458828ff33ece806cc2ce4443a
Goodman C. Engineering ingenuity at iGEM 2008 Nature Chemical Biology 16 http://www.scopus.com/inward/record.url?eid=2-s2.0-37249032831&amp;partnerID=40&amp;md5=464370c4b42769a4b3a9a8a717a1c206
Gallagher R. An iGEM of an idea 2007 Scientist 2 http://www.scopus.com/inward/record.url?eid=2-s2.0-37749033035&amp;partnerID=40&amp;md5=2963cb1a67d5ffe45b0bed31a43f7471
Brown J. The iGEM competition: Building with biology 2007 IET Synthetic Biology 7 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547756879&amp;partnerID=40&amp;md5=7a4f9ee6f657126d039b6d14c32facdf
Haynes K.A.; Broderick M.L.; Brown A.D.; Butner T.L.; Harden L.; Heard L.; Jessen E.; Malloy K.; Ogden B.; Rosemond S.; Simpson S.; Zwack E.; Campbell A.M.; Eckdahl T.; Heyer L.J.; Poet J.L. Computing with living hardware 2007 IET Synthetic Biology 2 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547766474&amp;partnerID=40&amp;md5=5cbb92ec25cb1f7c8948678ed87f1eb9
Dabholkar S.; Thattai M. Brainstorming biology 2007 IET Synthetic Biology 1 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547770766&amp;partnerID=40&amp;md5=1708fc19ef10eb3ad147917e93f98917
Brown T.; Chang C.; Heinze B.; Hollinger P.; Kittleson J.; MacDow K.; Reavis D.; Curry J.; Riley M. Development of an inducible three colour bacterial water colour system 2007 IET Synthetic Biology 1 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547792851&amp;partnerID=40&amp;md5=87694ffa9b4e84807270bcd42a7ea429
Rodrigo G.; Montagud A.; Aparici A.; Aroca M.C.; Baguena M.; Carrera J.; Edo C.; Fernandez-De-Cordoba P.; Ferrando A.; Fuertes G.; Gimenez D.; Mata C.; Medrano J.V.; Navarrete C.; Navarro E.; Salgado J.; Tortosa P.; Urchueguia J.; Jaramillo A. Vanillin cell sensor 2007 IET Synthetic Biology 1 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547815072&amp;partnerID=40&amp;md5=f455a6c61e37a0c6f9f6b7b9dfb78584
Quiroz J.N.A.; Flores R.B.; Cisneros T.G.B.; Rosales I.Y.F.; Naranjo A.G.; Sanchez J.C.G.; Jimenez M.E.G.; Padilla R.E.G.; Baena A.J.L.; Hernandez P.A.L.; Padilla P.G.; Miller R.P.; Gaspar I.N.R.; Chico J.C.R.; Martinez A.R.; Romero J.P.; Arzate A.S.; Barradas J.S.A.; Diaz D.A.; Bracho A.B.; Benitez C.; Arteag C.I.F.; Quiroz F.H.; Martinez G.J.; Rabadan J.L.; Salvador M.C.O.; Longoria P.P.; Orozco R.P.; Corona F.R.; Majarrez E.S.; Hassan E.S.; Sanchez C.S.; Saldana U.V.; Segura P.B.Z. Biological implementation of algorithms and unconventional computing 2007 IET Synthetic Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-34547735452&amp;partnerID=40&amp;md5=d8366832fc70edd0d1fe9fde991ec608
King P.; Lavrovsky V.; Von Mammen S.; Jacob C. Teaching bacteria how to dance 2007 IET Synthetic Biology http://www.scopus.com/inward/record.url?eid=2-s2.0-34547753985&amp;partnerID=40&amp;md5=ee8ac0a42229ae0664005b0e99f02df0
Badalamenti J.P.; Weiss L.E.; Buckno C.J.; Richard T.L.; Weiss P.S.; Cirino P.C. Synthetic sports: A bacterial relay race 2007 IET Synthetic Biology 1 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547744852&amp;partnerID=40&amp;md5=8845204e23c68968ca36d7c44e37fc3e
Lohmueller J.; Neretti N.; Hickey B.; Kaka A.; Gao A.; Lemon J.; Lattanzi V.; Goldstein P.; Tam L.-K.; Schmidt M.; Brodsky A.S.; Haberstroh K.; Morgan J.; Palmore T.; Wessel G.; Jaklenec A.; Urabe H.; Gagnon J.; Cumbers J. Progress toward construction and modelling of a tri-stable toggle switch in E. coli 2007 IET Synthetic Biology 2 http://www.scopus.com/inward/record.url?eid=2-s2.0-34547820240&amp;partnerID=40&amp;md5=32b2a39638653846cb463e3803da25e6
Ravi M.; Ngeleka M.; Kim S.-H.; Gyles C.; Berthiaume F.; Mourez M.; Middleton D.; Simko E. Contribution of AIDA-I to the pathogenicity of a porcine diarrheagenic Escherichia coli and to intestinal colonization through biofilm formation in pigs 2007 Veterinary Microbiology 10 http://www.scopus.com/inward/record.url?eid=2-s2.0-33846781661&amp;partnerID=40&amp;md5=9f9eddba925a109f0fe648b758895db6
Anim pariatur cliche reprehenderit, enim eiusmod high life accusamus terry richardson ad squid. 3 wolf moon officia aute, non cupidatat skateboard dolor brunch. Food truck quinoa nesciunt laborum eiusmod. Brunch 3 wolf moon tempor, sunt aliqua put a bird on it squid single-origin coffee nulla assumenda shoreditch et. Nihil anim keffiyeh helvetica, craft beer labore wes anderson cred nesciunt sapiente ea proident. Ad vegan excepteur butcher vice lomo. Leggings occaecat craft beer farm-to-table, raw denim aesthetic synth nesciunt you probably haven't heard of them accusamus labore sustainable VHS.

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University of St Andrews, 2012.

Contact us: igem2012@st-andrews.ac.uk, Twitter, Facebook

This iGEM team has been funded by the MSD Scottish Life Sciences Fund. The opinions expressed by this iGEM team are those of the team members and do not necessarily represent those of Merck Sharp & Dohme Limited, nor its Affiliates.