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Team:Evry/Project
From 2012.igem.org
Project overview
For our first participation in iGEM, we have decided to combine the future and the past, tradition with modernity and our project aims to combine Synthetic biology and the roots of french society: frogs. We will bring Xenopus, a model organism in developmental biology, to iGEM for the first time. We hope to show it can be a great multicellular chassis for the iGEM community. We will create tools for the next generation of iGEMers to be able to easily express synthetic systems in various tissues. In order to link all these parts together, we want to create an orthogonal, synthetic hormonal system using the plant hormone auxin, in order for the different tissues to communicate with one another.
A quick summary of each project is proposed in this page. Please go on the specific page of each project for more details!
The French Froggies: Engineering a new hormonal system in tadpoles
Xenopus is a model organism for develpmental biology, and Xenopus larvae are used as biosensors of water pollutants. Our aim is to pave the way towards integrated multicellular genetic circuits by creating a synthetic, orthogonal hormonal system. We want to use the plant hormone auxin for communication between organs, which would allow the creation of more advanced biosensors.
The us of a higher organism as a biosensor allows more meaningful measures of the dangers to humans than can be obtained with unicellular organisms. Furthermore, the use of a multicellular organism provides an additional level of complexity compared to single-celled organisms which multiplies the potential applications in terms of synthetic biology.
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Modeling a tadpole: a multi-level approach
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Biotic games: Better understanding of tadpole behavior through gaming
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Goldenbrick: Using type 2S restriction enzymes for biobricks
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