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From 2012.igem.org

Introduction

The Wageningen UR team has worked on the modification of virus-like particles (VLPs) to make them interesting platforms for vaccine production and/or site specific drug delivery. VLPs are empty virus capsids, meaning that they do not contain any viral genome and proteins except for the coat proteins. Coat proteins of some viruses have shown the ability to self-assemble in absence of its viral genome and other viral proteins, and thus form VLPs. Our human body model gives us an inside about how our drug delivery system would improve drug application.

Besides the work done in the wet lab on VLPs, the team developed a web based tool that simplifies the design of the best cloning strategy: The Constructor. The team cooperated with the 2011 Wageningen UR iGEM team for this project. Their experiences were used to further develop the tool adding features and making a user-friendly and easily accessible tool. This work has already been published.

Our Virus-Like particle will guide you through the project.