Team:SJTU-BioX-Shanghai/Parts5

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Violacein

12SJTU-VIO.png


[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771201 VioA with Membrane Anchor 2(without MS2) (BBa_K771201)]

[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771202 VioB with Membrane Anchor 3 Guo Huaqing;(BBa_K771202)]

[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771203 VioE with Membrane Anchor 4 Guo Huaqing (BBa_K771203)]

[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771204 VioC with Membrane Anchor 5(without VVD) (BBa_K771204)]

[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771205 VIoC with Membrane Anchor 5 (BBa_K771205)]

[http://partsregistry.org/wiki/index.php?title=Part:BBa_K771206 Viod with Membrane Anchor 6 (BBa_K771206)]

Violacein is a violet pigment produced by several bacteria through pathway of 5 related genes, vioA, vioB, vioC, vioD and vioE. It was initially discovered in Chromobacterium violaceum. This metabolite of tryptophan has such special applications as antibacterial, anti-trypanocidal, anti-ulcerogenic, and anticancer drugs. There are three branches in this pathway which could verify the efficiency of the Membrane Rudder.

In Violacein Membrane Rudder System, VioA, VioB, VioE and VioC constitutively aggregate. When blue light is present, VioD with Membrane Anchor would aggregate with complex of VioA,B,C and E, making violacein the dominnant final product.But if you turn the light off, VioD with Membrane Anchor would dissociate with VioA,B,C and E. Thus the biosynthetic pathway for deoxyviolacein is switched on.



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