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Team:ETH Zurich/Modeling/UVR8
From 2012.igem.org
Contents |
UVR8
UVR8 is a plant protein acting in a pathway to regulate COP and act as a UVB photoreceptor. Due to its
Circuit
The following circuit illustrates the general system properties
ODEs
File:UVR8 ODEs.png
Figure 1: List of ODEs for the UVR8 system.
Results
Plots
Outlook
As most cellular proteins containing tryptophan and tyrosine absorb in the UVB range, the theoretical calculations for the rate parameters are a first approximation. Taking this general background absorption into account will refine and provide for a more realistic model.
Another improvement to be included will focus on improving the negative feedback part of the model. Currently this negative feedback from pABA is modelled with a Hill-like inhibition - in future this should be from first principles which will require an effective absorbance cross-section (?!).
