Team:TU-Eindhoven/LEC/Modelling

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Calcium kinetics in yeast cells

To model the calcium homeostasis of yeast cells, a basic calcium model based on sympathetic ganglion “B” cells of a bullfrog is used. This is a type of nerve cells which exists in nerve junctions of the orthosympathetic nervous system. In the model, the main contributions of calcium transport are defined, namely ionic current flows of calcium, diffusion, buffering and pumping. This model will need to be adapted to a calcium model for yeast cells. Some information will be difficult to find in literature, especially when the yeast cells obtain fluorescent properties based on calcium kinetics. So yeast cell and enzyme specific information is also needed from experiments in the laboratory. This requires a strong collaboration between the team in the laboratory and the team responsible for modeling.