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Team:NTNU Trondheim/Project
From 2012.igem.org
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Overall project
Our goal for this years competition is to create a genetic circuit which enables E. coli cells to detect and attack cancer cells. To do this, the cells should produce a tumor inhibitor or toxin effective at killing cancer cells, and respond to environmental cues indicating the presence of cancer cells by undergoing lysis, releasing the anti-cancer agent into the surrounding environment. In principle, bacteria could be used in "search and destroy" missions against cancer inside the human body. We wish to develop our genetic circuit as a proof-of-concept of one such strategy.
A sketch of our current planned design for the circuit is shown below.
