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Team:Austin Texas
From 2012.igem.org
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<img src="https://static.igem.org/mediawiki/2012/d/d6/Austin_Texas_NEB_logo.jpeg" alt="NEB logo" width="150px" height="58px" style="float:right; padding:10px; clear:right;" /> | <img src="https://static.igem.org/mediawiki/2012/d/d6/Austin_Texas_NEB_logo.jpeg" alt="NEB logo" width="150px" height="58px" style="float:right; padding:10px; clear:right;" /> | ||
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| + | == Project ZombiE.coli == | ||
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| + | UT’s ZombiE.coli aims to a develop a tightly regulated genetic switch that is triggered by bacterial quorum signaling and leads to feed-forward propagation of the genetic output in the form of red or green fluorescence as well as amplification of quorum signaling. The switch relies on simple one-way Cre/loxP recombination combined with native quorum signaling to provide us with a system that models transmissible disease spread between populations. We have likened this to an airborne zombie epidemic, in which a an “infected” zombie cell is capable of restructuring the genes of a normal cell, turning it into a flesh-hungry counterpart. This system will be useful not only as a simple disease outbreak model for intermediate-level biology education, but also, could provide new insights to how bacterial populations communicate in three dimensions and under different genetic backgrounds. | ||
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Revision as of 22:27, 11 July 2012
Project ZombiE.coli
UT’s ZombiE.coli aims to a develop a tightly regulated genetic switch that is triggered by bacterial quorum signaling and leads to feed-forward propagation of the genetic output in the form of red or green fluorescence as well as amplification of quorum signaling. The switch relies on simple one-way Cre/loxP recombination combined with native quorum signaling to provide us with a system that models transmissible disease spread between populations. We have likened this to an airborne zombie epidemic, in which a an “infected” zombie cell is capable of restructuring the genes of a normal cell, turning it into a flesh-hungry counterpart. This system will be useful not only as a simple disease outbreak model for intermediate-level biology education, but also, could provide new insights to how bacterial populations communicate in three dimensions and under different genetic backgrounds.
