Team:Harvey Mudd/Notebook

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Latest revision as of 19:29, 21 June 2012

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From iGEM: You should make use of the calendar feature on the wiki and start a lab notebook. This may be looked at by the judges to see how your work progressed throughout the summer. It is a very useful organizational tool as well.

We might do that eventually. For now, we can keep track of progress here.

6/4: Last night I finally proved uniqueness for the steady-state equations for TALOR systems. The good news: that's done. The bad news: TALORs cannot build bistable systems without some other component. The model used also applies to TFOs.

6/19: A 1991 paper [http://pubs.acs.org/doi/abs/10.1021/ja00015a076 reported] successful use of TFOs with regions designed to dimerize. The two TFOs form a much more stable triplex after dimerization, exactly as needed for bistable circuit design. The downside is that it requires DNA oligos, and I have no idea how those come about in vivo.

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	6/4: Last night I finally proved uniqueness for the steady-state equations for TALOR systems. The good news: that's done. The bad news: TALORs cannot build bistable systems without some other component. The model used also applies to TFOs.		6/4: Last night I finally proved uniqueness for the steady-state equations for TALOR systems. The good news: that's done. The bad news: TALORs cannot build bistable systems without some other component. The model used also applies to TFOs.

-	6/19: A 1991 paper [[http://pubs.acs.org/doi/abs/10.1021/ja00015a076 \| reported]] successful use of TFOs with regions designed to dimerize. The two TFOs form a much more stable triplex after dimerization, exactly as needed for bistable circuit design. The downside is that it requires DNA oligos, and I have no idea how those come about in vivo.	+	6/19: A 1991 paper [http://pubs.acs.org/doi/abs/10.1021/ja00015a076 reported] successful use of TFOs with regions designed to dimerize. The two TFOs form a much more stable triplex after dimerization, exactly as needed for bistable circuit design. The downside is that it requires DNA oligos, and I have no idea how those come about in vivo.