"
Team:Wageningen UR
From 2012.igem.org
TSlijkhuis (Talk | contribs) |
TSlijkhuis (Talk | contribs) |
||
| Line 3: | Line 3: | ||
<html> | <html> | ||
| - | <script> | + | <script>document.getElementById("header_slider").style.backgroundImage = "url(https://static.igem.org/mediawiki/2012/c/c4/Slider2.jpg)";</script> |
<div id="projectIntro"> | <div id="projectIntro"> | ||
Revision as of 10:11, 19 September 2012
Abstract
A standardized tool for site specific drug delivery using Virus-Like Particles
Medicines are generally active in a non-site-specific fashion, affecting the whole patient, including healthy tissue. Therefore, we attempt to specifically target diseased areas by packaging medicines inside Virus-Like Particles (VLPs). VLPs are not infectious, as they are built solely from viral coat proteins. We designed a modular Plug and Apply system that enables modifications to these coat proteins. The system facilitates the linkage of numerous ligands to the coat protein, thereby creating site-specific carriers. After expression of coat protein genes in Escherichia coli the VLPs were assembled in vitro, yielding modified Virus-Like Particles. Medicines can be packed using the Plug and Apply system or simply by addition during VLP assembly. Concluding, VLPs can be used as universal carriers for site-specific drug delivery, allowing customization to a variety of diseases while decreasing side effects for patients during treatment.
The Constructor
An application that assists you in creating your cloning strategies for your iGEM project.
