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Team:NTU-Taida
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Revision as of 07:18, 15 July 2012
Project Description: Bio-Molecular Synthetic Chain For Human Diseases
- Rapid development of genetic technology applied in a wide spectrum of areas, agriculture, environmental protection, anti-microbial, synonymous to biofouling. The basic concept is simple, that is how to manipulate our microbes to express and secret certain chemicals. As a medical-based lab, we try to manipulate the attractive microbial production technology into our project design for targeting human diseases.
- As E. coli based microbial secretory systems, we found it efficient to secret synthetic long peptides, rather than a protein. Synthetic peptides have multiple roles in human diseases, ranging from anti-cancer, anti-allergy vaccine, neuro-endocrinology supplement. However, different therapeutic trials of synthetic peptides require different circuit design for secretion, especially in its diverse biochemical rhythm from which we simulates its natural secretory pattern or therapeutic regimen of desire.
- In our project, we take three peptide for examples, GLP-1, which is a neuro-endocrine for metabolic control, and synthetic long peptides for anti-cancer vaccine and anti-allergy, and by using mathematical and computation engineering, we design circuits respectively, try to understand its effect either intercellular or in multicellular structures. In addition, we also bring partition system to our circuit, which largely circumvent the instability of plasmid in engineered bacterial production secretion system. Hence, we are expecting to bring a novel and stable delivery system for synthetic peptides targeting human diseases.
