Team:NTNU Trondheim/Notebook/April
From 2012.igem.org
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Our final project idea is then to make bacteria, for example E.coli cells, produce anti cancer drugs; preferably as many different molecules as possible. We have read about both enzymes and endpoints of metabolic pathways that are disadvantageous for cancer cells. | Our final project idea is then to make bacteria, for example E.coli cells, produce anti cancer drugs; preferably as many different molecules as possible. We have read about both enzymes and endpoints of metabolic pathways that are disadvantageous for cancer cells. | ||
Our engineered cells should also be able to respond to a signal molecule secreted in larger amounts from cancer cells than from normal cells, for example a signaling molecule that promotes angiogenesis. | Our engineered cells should also be able to respond to a signal molecule secreted in larger amounts from cancer cells than from normal cells, for example a signaling molecule that promotes angiogenesis. | ||
- | When the cells detect the signal molecule from | + | When the cells detect the signal molecule from thabe cancer cells, they should lyse, releasing the anti cancer molecule close to the tumour. |
Another approach to reach the tumour could be to take advantage of the fact that the environment inside tumours normally is oxygen deficient. And as E.coli cells naturally migrate towards areas low in oxygen, a possible solution is also to activate the lysis gene when the cells are in an are with little oxygen. | Another approach to reach the tumour could be to take advantage of the fact that the environment inside tumours normally is oxygen deficient. And as E.coli cells naturally migrate towards areas low in oxygen, a possible solution is also to activate the lysis gene when the cells are in an are with little oxygen. | ||
Rahmi told us about a promoter that gets activated by low concentration of O<sub>2</sub>. This could regulate the lysis genes. | Rahmi told us about a promoter that gets activated by low concentration of O<sub>2</sub>. This could regulate the lysis genes. | ||
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Today, we decided on the overall top three projects for the team. We added the points all the team members have given to the different projects, and the list then becomes as follows: | Today, we decided on the overall top three projects for the team. We added the points all the team members have given to the different projects, and the list then becomes as follows: | ||
- | {|class=" | + | {|class="table sortable" style="margin: 1em auto 1em auto; width: auto;" |
!Project | !Project | ||
!Number of points | !Number of points |
Revision as of 17:44, 23 September 2012