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Team:Wageningen UR
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| - | < | + | <h1>Abstract</h1> |
| - | + | <h4>A standardized tool for site specific drug delivery using Virus-Like Particles</h4> | |
| - | < | + | <p>Medicines are generally active in a non-site-specific fashion, affecting the whole patient, including healthy tissue. Therefore, we attempt to specifically target diseased areas by packaging medicines inside Virus-Like Particles (VLPs). VLPs are not infectious, as they are built solely from viral coat proteins. We designed a modular Plug and Apply system that enables modifications to these coat proteins. The system facilitates the linkage of numerous ligands to the coat protein, thereby creating site-specific carriers. After expression of coat protein genes in Escherichia coli the VLPs were assembled in vitro, yielding modified Virus-Like Particles. Medicines can be packed using the Plug and Apply system or simply by addition during VLP assembly. Concluding, VLPs can be used as universal carriers for site-specific drug delivery, allowing customization to a variety of diseases while decreasing side effects for patients during treatment.</p> |
<iframe width="305" height="229" src="http://www.youtube.com/embed/h-Db1gwOcTo?autoplay=1&rel=0&loop=1" frameborder="0" allowfullscreen></iframe> | <iframe width="305" height="229" src="http://www.youtube.com/embed/h-Db1gwOcTo?autoplay=1&rel=0&loop=1" frameborder="0" allowfullscreen></iframe> | ||
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| - | + | <a href="https://2012.igem.org/Team:Wageningen_UR/TheConstructor" title="Project Description" class="bigbutton" style="background: #b92c33;"> | |
| - | <a href="https://2012.igem.org/Team:Wageningen_UR/ | + | <span>The Constructor. An application that assists you in creating your cloning strategies for your iGem project.</span> |
| + | </a> | ||
<br /><br /> | <br /><br /> | ||
| - | <a href="https://2012.igem.org/Team:Wageningen_UR/ | + | <a href="https://2012.igem.org/Team:Wageningen_UR/Team" title="Meet the Team" class="bigbutton"><img src="http://www.the-falcons.nl/igem2/img/theteam.png" alt="The Project" /></a> |
| - | + | ||
| - | </a> | + | |
</div> | </div> | ||
Revision as of 13:27, 10 September 2012
P'NAS
Coming soon...
VLPs' origins
Coming soon...
Outside modification
Coming soon...
Inside modification
Coming soon...
Applications
Coming soon...
Abstract
A standardized tool for site specific drug delivery using Virus-Like Particles
Medicines are generally active in a non-site-specific fashion, affecting the whole patient, including healthy tissue. Therefore, we attempt to specifically target diseased areas by packaging medicines inside Virus-Like Particles (VLPs). VLPs are not infectious, as they are built solely from viral coat proteins. We designed a modular Plug and Apply system that enables modifications to these coat proteins. The system facilitates the linkage of numerous ligands to the coat protein, thereby creating site-specific carriers. After expression of coat protein genes in Escherichia coli the VLPs were assembled in vitro, yielding modified Virus-Like Particles. Medicines can be packed using the Plug and Apply system or simply by addition during VLP assembly. Concluding, VLPs can be used as universal carriers for site-specific drug delivery, allowing customization to a variety of diseases while decreasing side effects for patients during treatment.
