Team:USTC-China

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==Project description==
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This year, USTC-China iGEMers are going to provide a novel immune system of engineering bacteria to fight against the bacteriophage. We hope this artificial line of defeat composed of gene circuits can be of practical use in fermentation industry.
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Since the fermentation industry appeared, the phage infection has become a big threat to engineering bacteria. During mass production of dairy products, enzymes, amino acids, antibiotics and pesticides, the results would be unimaginable if bacteria were infected by bacteriophages. Bacteria will be abnormal and die and the infection will spread quickly. Without any efficient strategy, tremendous loss will lie ahead. Nowadays, common strategy for avoiding this catastrophe is to control the conditions of the fermentation strictly. Meanwhile, people keep selecting strains against phages. But all the strategies are time-consuming and far from once-for-all.
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However, the engineering bacteria which 2012 USTC-China iGEMers hope to cultivate would both protect themselves when bacteriophage invades the strain and focus on producing products without consuming extra energy when their living condition is safe. In this case, the quality of fermented products can be guaranteed and the profits of fermentation industry can be enormously improved.
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[[File:Project Map.jpg]]
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<div id="ustc">
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<a href="http://wcm.ustc.edu.cn/pub/en_new/" >
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  <a href="https://2012.igem.org/Team:USTC-China">Home
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  <h3>Front page</h3>
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  <li id="kwick_2">
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  <a href="https://2012.igem.org/Team:USTC-China/background">Project
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  <h3>lambda phage</h3>
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    </a>
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  </li>
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  <li id="kwick_3">
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  <a href="https://2012.igem.org/Team:USTC-China/results">Achievements
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  <h3>What we get</h3>
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    </a>
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  </li>
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  <li id="kwick_4">
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  <a href="https://2012.igem.org/Team:USTC-China/modeling">Modeling
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  <h3>Analytic</h3>
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    </a>
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  </li>
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  <li id="kwick_5">
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  <a href="https://2012.igem.org/Team:USTC-China/outreach">Outreach
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  <h3>HumanPractice</h3>
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  </li>
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  <li id="kwick_6">
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  <a href="https://2012.igem.org/Team:USTC-China/protocols">Notes
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  <h3>Daily Recordings</h3>
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    </a>
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  </li>
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  <li id="kwick_7">
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  <a href="https://2012.igem.org/Team:USTC-China/team">Team
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  <h3>Members</h3>
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  </ul>
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<div id="welcome">
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<P>WELCOME TO THE WIKI OF USTC-CHINA IGEM TEAM! ENJOY YOUR EXPLORATION!</P>
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<a href="https://2012.igem.org/Team:USTC-China/parts" class="one">PARTS</a>
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<p class="button">This summer we have contributed 22 parts to the partsregistry!</p>
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<div id="option2" >
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<a href="https://2012.igem.org/Team:USTC-China/modeling">MODELING</a>
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<p class="button">We have theoretically analysed our system through Mathematical Modeling!</p>
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<div id="option3" >
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<a href="https://2012.igem.org/Team:USTC-China/outreach">OUTREACH</a>
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<p class="button">Our team have conducted several activities for public recognition of synthetic biology!</p>
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</div>
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<div id="option4">
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<a href="https://2012.igem.org/Team:USTC-China/safety">SAFETY</a>
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<p class="button">The project is considered to have the minimal risks!</p>
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<div id="option5" >
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<a href="https://2012.igem.org/Team:USTC-China/team">TEAM</a>
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<p class="button2">Members in USTC_China enjoyed themselves this summer!</p>
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<h3>WELCOME!</h3>
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<p class="project">Bacteriophage is one of the severest threats to fermentation factories. To help solve the problem, we design a gene circuit which can both sense and defend against phages. We use the modified promoter pRM to sense the phage’s infection and initiate the defence. The lysis gene which can make bacteria lyse is installed to our circuit. When it works, the phage won’t be able to take advantage of its host to replicate any longer. To win more time for lysis to function well, we design an antisense RNA to prevent the phage from turning into lytic life cycle. Thus, when the lysis protein kills the host, the phage is still at lysogenic life cycle or the newly assembled phages are still immature. By using the quorum sensing system, the bacteria around the host can make well preparation to defend in advance. Attribute to these parts, our bacteria survive.</p>
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<br>
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<div class="more" style="padding:5px;width:150px;height:30px;margin-left:500px;">
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<p class="button"><a href="https://2012.igem.org/Team:USTC-China/background">more</a></p>
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</div>
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<div id="ustcsponsor" >
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  <p class="big">SPONSORS</p></br>
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  <a href="http://china.db.com/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/0/0c/Deutsche_bank.jpg" /></a>
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  <a href="http://www.ustcif.org/" ><img src="https://static.igem.org/mediawiki/2012/3/36/Ustcif.jpg" style="height:99px;width:98px;float:left;margin-left:10px;"/></a>
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  <a href="http://en.gradschool.ustc.edu.cn/" ><img src="https://static.igem.org/mediawiki/2012/7/79/GRADUATE.png" style="float:left;margin-left:10px;"/></a>
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  <a href="http://www.teach.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/7/79/Teaching.jpg" /></a>
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  <a href="http://en.biox.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/archive/5/5e/20120830175936%21Life.jpg" /></a>
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  <a href="http://en.physics.ustc.edu.cn/" style="float:left;margin-left:10px;"><img src="https://static.igem.org/mediawiki/2012/a/ac/Phy.png" /></a>
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  <a href="http://en.scgy.ustc.edu.cn/" ><img src="https://static.igem.org/mediawiki/2012/f/f1/Gifted_young.jpg" style="width:330px;height:85px;float:left;margin-left:10px;"/></a>
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<a href="#top">backtotop</a></div>

Latest revision as of 03:21, 28 September 2013

WELCOME TO THE WIKI OF USTC-CHINA IGEM TEAM! ENJOY YOUR EXPLORATION!

PARTS

This summer we have contributed 22 parts to the partsregistry!

MODELING

We have theoretically analysed our system through Mathematical Modeling!

OUTREACH

Our team have conducted several activities for public recognition of synthetic biology!

SAFETY

The project is considered to have the minimal risks!

TEAM

Members in USTC_China enjoyed themselves this summer!

WELCOME!

Bacteriophage is one of the severest threats to fermentation factories. To help solve the problem, we design a gene circuit which can both sense and defend against phages. We use the modified promoter pRM to sense the phage’s infection and initiate the defence. The lysis gene which can make bacteria lyse is installed to our circuit. When it works, the phage won’t be able to take advantage of its host to replicate any longer. To win more time for lysis to function well, we design an antisense RNA to prevent the phage from turning into lytic life cycle. Thus, when the lysis protein kills the host, the phage is still at lysogenic life cycle or the newly assembled phages are still immature. By using the quorum sensing system, the bacteria around the host can make well preparation to defend in advance. Attribute to these parts, our bacteria survive.


more

SPONSORS


backtotop

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